Diversity in CD8+ T cell differentiation

被引：60

作者：

Parish, Ian A. ^{[1
]}

Kaech, Susan M. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2009年 / 21卷 / 03期

关键词：

CHRONIC VIRAL-INFECTION; CUTTING EDGE; IN-VIVO; MEMORY CELLS; TERMINAL DIFFERENTIATION; DELETIONAL TOLERANCE; TRANSCRIPTION FACTOR; MOLECULAR SIGNATURE; PERIPHERAL DELETION; CROSS-PRESENTATION;

D O I：

10.1016/j.coi.2009.05.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD8(+) T cells are key effector cells of the adaptive immune system, however their activity must be tightly regulated to allow pathogen clearance whilst preventing immunopathology and autoimmunity. In this review, we summarise the diversity of responses that CD8(+) T cells make to antigenic stimulation with a focus on how CD8(+) T cell responses are regulated to achieve different immune outcomes. In particular, we discuss phenotypic diversity during tolerance induction as well as signals that drive effector and memory cell differentiation in response to infection.

引用

页码：291 / 297

页数：7

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