Temperature and glucose dual-responsive carriers bearing poly(N-isopropylacrylamide) and phenylboronic acid for insulin-controlled release: A review

被引：9
作者：
Li, Jiaxing [1 ]
Yang, Lei [1 ]
Fan, Xiaoguang [2 ]
Zhang, Jing [1 ]
Wang, Fei [1 ]
Wang, Zhanyong [1 ]
机构：
[1] Liaoning Shihua Univ, Sch Environm & Biol Engn, Fushun 113001, Peoples R China
[2] Shenyang Agr Univ, Coll Engn, Shenyang, Peoples R China
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2017年 / 66卷 / 11期
基金：
中国国家自然科学基金;
关键词：
Dual-responsive material; insulin-controlled release; phenylboronic acid; poly(N-isopropylacrylamide); DRUG-RELEASE; PHYSIOLOGICAL TEMPERATURE; SENSING MOIETY; MICROGELS; DELIVERY; NANOPARTICLES; NANOSPHERES; MICELLES; KINETICS; BEHAVIOR;
D O I：
10.1080/00914037.2016.1263954
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Insulin injection is a definitive therapy for diabetic patients, but mismatched dosage and untimely intervention lead to wide fluctuations in blood sugar levels. Therefore it is essential to combine exogenous insulin and intelligent carriers, which is promising to normalize glucose concentrations. The temperature and glucose dual-responsive materials bearing poly(N-isopropylacrylamide) (PNIPAAm) and phenylboronic acid (PBA) have been confirmed for insulin-controlled release in experimental stages. The recent progress on different types of smart PNIPAAm and PBA-containing carriers is summarized in this review. The new challenges and future direction regarding the studies on elaborate insulin-controlled-release systems are also proposed.
引用
收藏
页码：577 / 587
页数：11
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