The GABA nervous system in C. elegans

被引：119
作者：
Schuske, K [1 ]
Beg, AA [1 ]
Jorgensen, EM [1 ]
机构：
[1] Univ Utah, Dept Biol, Salt Lake City, UT 84112 USA
来源：
TRENDS IN NEUROSCIENCES | 2004年 / 27卷 / 07期
关键词：
D O I：
10.1016/j.tins.2004.05.005
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
GABA neurotransmission requires a specialized set of proteins to synthesize, transport or respond to GABA. This article reviews results from a genetic strategy in the nematode Caenorhabditis elegans designed to identify the genes responsible for these activities. These studies identified mutations in genes encoding five different proteins: the biosynthetic enzyme for GABA, the vesicular GABA transporter, a transcription factor that determines GABA neuron identity, a classic inhibitory GABA receptor and a novel excitatory GABA receptor. This review discusses the strategy employed to identify these genes as well as the conclusions about GABA transmission derived from study of the mutant phenotypes.
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收藏
页码：407 / 414
页数：8
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