Phosphorescent Iridium(III) Complexes for Bioimaging

被引:22
作者
Zhang, Kenneth Yin [1 ]
Liu, Shujuan [1 ]
Zhao, Qiang [1 ]
Li, Fuyou [2 ]
Huang, Wei [1 ,3 ,4 ]
机构
[1] Nanjing Univ Posts & Telecommun, Inst Adv Mat, Key Lab Organ Elect & Informat Displays, Nanjing 210023, Jiangsu, Peoples R China
[2] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
[3] Nanjing Tech Univ, Inst Adv Mat, Nanjing 211816, Jiangsu, Peoples R China
[4] Nanjing Tech Univ, Jiangsu Singapore Joint Res Ctr Organ Bioelect &, Nanjing 211816, Jiangsu, Peoples R China
来源
LUMINESCENT AND PHOTOACTIVE TRANSITION METAL COMPLEXES AS BIOMOLECULAR PROBES AND CELLULAR REAGENTS | 2015年 / 165卷
基金
中国国家自然科学基金;
关键词
Bioimaging probes; Biosensors; Chemosensors; Iridium(III) complexes; Phosphorescent materials; FREE CLICK CHEMISTRY; LIVING CELLS; POLYPYRIDINE COMPLEXES; CELLULAR UPTAKE; NITRIC-OXIDE; POLYMER NANOPARTICLES; INTRACELLULAR UPTAKE; MULTICOLOR PROBES; RATIONAL DESIGN; METAL-COMPLEXES;
D O I
10.1007/430_2014_166
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Phosphorescent iridium(III) complexes have received increasing attention in bioimaging applications owing to their advantageous photophysical properties and efficient internalization into live cells. In this chapter, we summarize the recent design of bioimaging reagents based on phosphorescent iridium(III) complexes. The utilizations of cationic, neutral, and zwitterionic phosphorescent iridium(III) complexes in bioimaging applications have been described first. Complexes showing aggregation-induced phosphorescence have also been included considering the absence of the commonly observed aggregation-caused quenching. Then we discuss the functionalization of iridium(III) complexes with biological substrates and reactive groups, which allows non-covalent and covalent interaction, respectively, with intracellular biomolecules. As the photophysical properties of iridium(III) complexes are very sensitive toward their surrounding ligands and microenvironment, the use of these complexes as intracellular sensors for gas molecules, ions, and amino acids has been summarized. Additionally, the incorporation of iridium(III) complexes into dendrimer, polymer, and nanoparticle systems providing attractive functionalities has been discussed. Furthermore, various strategies, including the use of near-infrared-emitting and two-photon excitable complexes, upconversion nanoparticles, and lifetime-based microscopy techniques, to enhance signal-to-noise ratios in bioimaging have been discussed. At last, the design of reagents for multi-mode imaging techniques involving phosphorescence and magnetic resonance imaging has been described.
引用
收藏
页码:131 / 180
页数:50
相关论文
共 50 条
  • [31] Design strategies of iridium(III) complexes for highly efficient saturated blue phosphorescent OLEDs with improved lifetime
    Wu, Chengcheng
    Shi, Kefei
    Li, Siqi
    Yan, Jie
    Feng, Zi-Qi
    Tong, Kai-Ning
    Zhang, Si -Wei
    Zhang, Yuewei
    Zhang, Dongdong
    Liao, Liang-Sheng
    Chi, Yun
    Wei, Guodan
    Kang, Feiyu
    ENERGYCHEM, 2024, 6 (02)
  • [32] Phosphorescent cationic iridium(III) complexes dynamically bound to cyclodextrin vesicles: applications in live cell imaging
    Schibilla, Frauke
    Holthenrich, Anna
    Song, Boyi
    Matos, Anna Livia Linard
    Grill, David
    Martir, Diego Rota
    Gerke, Volker
    Zysman-Colman, Eli
    Ravoo, Bart Jan
    CHEMICAL SCIENCE, 2018, 9 (40) : 7822 - 7828
  • [33] Recent Progress on the Exploration of the Biological Utility of Cyclometalated Iridium(III) Complexes
    You, Youngmin
    JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2018, 65 (03) : 352 - 367
  • [34] Microwave-assisted facile and expeditive syntheses of phosphorescent cyclometallated iridium(III) complexes
    Alam, Parvej
    Laskar, Inamur Rahaman
    Climent, Claudia
    Casanova, David
    Alemany, Pere
    Karanam, Maheswararao
    Choudhury, Angshuman Roy
    Butcher, J. Raymond
    POLYHEDRON, 2013, 53 : 286 - 294
  • [35] Chiral phosphorescent probes for amino acids: hybrids of iridium(III) complexes with synthetic saponite
    Sato, Hisako
    Tamura, Kenji
    Yajima, Tomoko
    Sato, Fumi
    Yamagishi, Akihiko
    NEW JOURNAL OF CHEMISTRY, 2017, 41 (07) : 2780 - 2785
  • [36] Rational Design of Cyclometalated Iridium(III) Complexes for Three-Photon Phosphorescence Bioimaging
    Jin, Chengzhi
    Liang, Fengyin
    Wang, Jinquan
    Wang, Lili
    Liu, Jiangping
    Liao, Xinxing
    Rees, Thomas W.
    Yuan, Bo
    Wang, Hui
    Shen, Yong
    Pei, Zhong
    Ji, Liangnian
    Chao, Hui
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 59 (37) : 15987 - 15991
  • [37] Circularly Polarized Phosphorescent Electroluminescence from Chiral Cationic Iridium(III) Isocyanide Complexes
    Han, Jianmei
    Guo, Song
    Wang, Jiong
    Wei, Liuwei
    Zhuang, Yanling
    Liu, Shujuan
    Zhao, Qiang
    Zhang, Xinwen
    Huang, Wei
    ADVANCED OPTICAL MATERIALS, 2017, 5 (22):
  • [38] Mitochondrial Dynamics Tracking with Two-Photon Phosphorescent Terpyridyl Iridium(III) Complexes
    Huang, Huaiyi
    Zhang, Pingyu
    Qiu, Kangqiang
    Huang, Juanjuan
    Chen, Yu
    Ji, Liangnian
    Chao, Hui
    SCIENTIFIC REPORTS, 2016, 6
  • [39] Mitochondria-specific imaging and tracking in living cells with two-photon phosphorescent iridium(III) complexes
    Qiu, Kangqiang
    Huang, Huaiyi
    Liu, Bingyang
    Liu, Yukang
    Zhang, Pingyu
    Chen, Yu
    Ji, Liangnian
    Chao, Hui
    JOURNAL OF MATERIALS CHEMISTRY B, 2015, 3 (32) : 6690 - 6697
  • [40] Investigation on the photophysical properties of a series of promising phosphorescent iridium (III) complexes with modified cyclometalating ligands
    Shang, Chunyu
    Jiang, Hongxi
    Wei, Yingzhi
    Zhang, Lin
    Luo, Ruyi
    POLYHEDRON, 2019, 157 : 170 - 176