Regulation of haematopoietic stem cells self-renenwal and the role of wnt signaling in the process

被引：0

作者：

Zhang, HJ ^{[1
]}

Miao, ZC ^{[1
]}

Wang, Y ^{[1
]}

Feng, MF ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100080, Peoples R China

来源：

PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2004年 / 31卷 / 07期

关键词：

HSCs; self-renewal; regulation; wnt signaling pathway;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanisms of regulating stem cells self-renewal is one of the most important issues in stem cell biology. Haematopoietic stem cells (HSCs) have the ability to renew themselves and to differentiate into all lineages of the blood but, the mechanism that control HSCs self-renewal remain unclear. Most researches showed it was controled by the signal and growth factors from the microenvironment and the cell-autonomous components. The writ signaling pathway plays an important role in this process. The HSCs self-renewal, the mechanism, the role of wnt signaling pathway and the perspectives of application and research in this field are discussed.

引用

页码：579 / 583

页数：5

共 33 条

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