A metastable DWARF1 epigenetic mutant affecting plant stature in rice

被引：149

作者：

Miura, Kotaro ^{[1
]}

Agetsuma, Masakazu ^{[1
]}

Kitano, Hidemi ^{[1
]}

Yoshimura, Atsushi ^{[2
]}

Matsuoka, Makoto ^{[1
]}

Jacobsen, Steven E. ^{[3
,4
]}

Ashikari, Motoyuki ^{[1
]}

机构：

[1] Nagoya Univ, Biosci & Biotechnol Ctr, Nagoya, Aichi 4648601, Japan

[2] Kyushu Univ, Fac Agr, Fukuoka 8128581, Japan

[3] Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90095 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2009年 / 106卷 / 27期

关键词：

DNA METHYLATION; MOLECULAR DISSECTION; HISTONE; PROTEIN; AGROBACTERIUM; PARAMUTATION;

D O I：

10.1073/pnas.0901942106

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Epigenetic mutations confer heritable changes in gene expression that are not due to changes in the underlying sequence of the DNA. We identified a spontaneous rice mutant, Epi-d1, that shows a metastable dwarf phenotype. The phenotype is mitotically and meiotically inheritable and corresponds to the metastable epigenetic silencing of the DWARF1 (D1) gene. The silenced state is correlated with repressive histone and DNA methylation marks in the D1 promoter region but is not associated with DNA sequence alterations. Compared with other known epigenetic silenced loci in plants such as paramutable maize alleles and silent Arabidopsis genes, the Epi-d1 silencing phenomenon shows a high level of bidirectional metastable mutability. Epigenetic alleles such as Epi-d1 could thus provide for rapid adaptation under selective conditions.

引用

页码：11218 / 11223

页数：6

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