Regulatory Mechanisms of the NLRP3 Inflammasome, a Novel Immune-Inflammatory Marker in Cardiovascular Diseases

被引:96
作者
An, Na [1 ,2 ]
Gao, Yonghong [2 ]
Si, Zeyu [3 ]
Zhang, Hanlai [2 ]
Wang, Liqin [2 ]
Tian, Chao [1 ,2 ]
Yuan, Mengchen [1 ,2 ]
Yang, Xinyu [1 ,2 ]
Li, Xinye [1 ,4 ]
Shang, Hongcai [2 ]
Xiong, Xingjiang [1 ]
Xing, Yanwei [1 ]
机构
[1] China Acad Chinese Med Sci, Guanganmen Hosp, Beijing, Peoples R China
[2] Beijing Univ Chinese Med, Dongzhimen Hosp, Minist Educ & Beijing, Key Lab Chinese Internal Med, Beijing, Peoples R China
[3] Shanxi Univ Chinese Med, Dept Acupuncture & Moxibust, Taiyuan, Shanxi, Peoples R China
[4] Beijing Univ Chinese Med, Dept Acupuncture & Moxibust, Beijing, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷
基金
国家重点研发计划; 中国国家自然科学基金;
关键词
NLRP3; inflammasome; cardiovascular diseases; immune-inflammatory; coronary atherosclerosis; myocardial ischemia/reperfusion; CORONARY-HEART-DISEASE; MYOCARDIAL-INFARCTION; ISCHEMIA-REPERFUSION; NALP3; INFLAMMASOME; PRESSURE-OVERLOAD; ENDOTHELIAL-CELLS; CARDIAC-FUNCTION; ACTIVATION; INHIBITION; EXPRESSION;
D O I
10.3389/fimmu.2019.01592
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The nod-like receptor family pyrin domain containing 3 (NLRP3) is currently the most widely studied inflammasome and has become a hot topic of recent research. As a macromolecular complex, the NLRP3 inflammasome is activated to produce downstream factors, including caspase-1, IL-1 beta, and IL-18, which then promote local inflammatory responses and induce pyroptosis, leading to unfavorable effects. A growing number of studies have examined the relationship between the NLRP3 inflammasome and cardiovascular diseases (CVDs). However, some studies have shown that the NLRP3 inflammasome is not involved in the occurrence of certain diseases. Therefore, identifying the mechanism of action of the NLRP3 inflammasome and its potential involvement in the pathological process of disease progression is of utmost importance. This review discusses the mechanisms of NLRP3 inflammasome activation and the relationship between the inflammasome and CVDs, including coronary atherosclerosis, myocardial ischemia/reperfusion, cardiomyopathies, and arrhythmia, as well as CVD-related treatments.
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页数:11
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