Diverse molecular interactions of the hnRNP K protein

被引：155
作者：
Bomsztyk, K
VanSeuningen, I
Suzuki, H
Denisenko, O
Ostrowski, J
机构：
[1] Unité INSERM 377, 59045 Lille Cedex, Place de Verdun
[2] Oncology Center
[3] Department of Medicine, University of Washington, Seattle
来源：
FEBS LETTERS | 1997年 / 403卷 / 02期
基金：
美国国家卫生研究院;
关键词：
K protein; docking platform; KH domain;
D O I：
10.1016/S0014-5793(97)00041-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The hnRNP K protein is a versatile molecule that interacts with RNA, DNA, the proto-oncoprotein VaV, Src-like tyrosine and inducible serine/threonine kinases, the transcription factor TBP and a number of zinc-finger transcriptional repressors. The interaction of K protein with some of its protein partners is modulated by nucleic acids and K protein can alter the in vivo and in vitro rate of transcription. K protein can simultaneously engage several proteins and may facilitate molecular cross-talk. Taken together these diverse interactions suggest that K protein may act as a nucleic acid-regulated docking platform. (C) 1997 Federation of European Biochemical Societies.
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页码：113 / 115
页数：3
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