Diverse molecular interactions of the hnRNP K protein

被引：155
作者：
Bomsztyk, K
VanSeuningen, I
Suzuki, H
Denisenko, O
Ostrowski, J
机构：
[1] Unité INSERM 377, 59045 Lille Cedex, Place de Verdun
[2] Oncology Center
[3] Department of Medicine, University of Washington, Seattle
来源：
FEBS LETTERS | 1997年 / 403卷 / 02期
基金：
美国国家卫生研究院;
关键词：
K protein; docking platform; KH domain;
D O I：
10.1016/S0014-5793(97)00041-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The hnRNP K protein is a versatile molecule that interacts with RNA, DNA, the proto-oncoprotein VaV, Src-like tyrosine and inducible serine/threonine kinases, the transcription factor TBP and a number of zinc-finger transcriptional repressors. The interaction of K protein with some of its protein partners is modulated by nucleic acids and K protein can alter the in vivo and in vitro rate of transcription. K protein can simultaneously engage several proteins and may facilitate molecular cross-talk. Taken together these diverse interactions suggest that K protein may act as a nucleic acid-regulated docking platform. (C) 1997 Federation of European Biochemical Societies.
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收藏
页码：113 / 115
页数：3
相关论文
共 28 条
[1]  
BUSTELO XR, 1995, MOL CELL BIOL, V15, P1324
[2]   IDENTIFICATION, MOLECULAR-CLONING, EXPRESSION AND CHROMOSOME MAPPING OF A FAMILY OF TRANSFORMATION UP-REGULATED HNRNP-K PROTEINS DERIVED BY ALTERNATIVE SPLICING [J].
DEJGAARD, K ;
LEFFERS, H ;
RASMUSSEN, HH ;
MADSEN, P ;
KRUSE, TA ;
GESSER, B ;
NIELSEN, H ;
CELIS, JE .
JOURNAL OF MOLECULAR BIOLOGY, 1994, 236 (01) :33-48
[3]   Zik1, a transcriptional repressor that interacts with the heterogeneous nuclear ribonucleoprotein particle K protein [J].
Denisenko, ON ;
ONeill, B ;
Ostrowski, J ;
VanSeuningen, I ;
Bomsztyk, K .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (44) :27701-27706
[4]   A SEQUENCE-SPECIFIC SINGLE-STRAND-BINDING PROTEIN FOR THE LATE-CODING STRAND OF THE SIMIAN VIRUS-40 CONTROL REGION [J].
GAILLARD, C ;
WEBER, M ;
STRAUSS, F .
JOURNAL OF VIROLOGY, 1988, 62 (07) :2380-2385
[5]   SEQUENCE-SPECIFIC SINGLE-STRAND-BINDING PROTEIN FOR THE SIMIAN VIRUS-40 EARLY PROMOTER STIMULATES TRANSCRIPTION INVITRO [J].
GAILLARD, C ;
STRAUSS, F .
JOURNAL OF MOLECULAR BIOLOGY, 1990, 215 (02) :245-255
[6]   THE KH DOMAIN OCCURS IN A DIVERSE SET OF RNA-BINDING PROTEINS THAT INCLUDE THE ANTITERMINATOR NUSA AND IS PROBABLY INVOLVED IN BINDING TO NUCLEIC-ACID [J].
GIBSON, TJ ;
THOMPSON, JD ;
HERINGA, J .
FEBS LETTERS, 1993, 324 (03) :361-366
[7]   CLONING AND CHARACTERIZATION OF A SINGLE-STRANDED-DNA BINDING-PROTEIN THAT SPECIFICALLY RECOGNIZES DEOXYCYTIDINE STRETCH [J].
ITO, K ;
SATO, K ;
ENDO, H .
NUCLEIC ACIDS RESEARCH, 1994, 22 (01) :53-58
[8]  
Lee MH, 1996, J BIOL CHEM, V271, P3420
[9]   The human p62 cDNA encodes Sam68 and not the RasGAP-associated p62 protein [J].
Lock, P ;
Fumagalli, S ;
Polakis, P ;
McCormick, F ;
Courtneidge, SA .
CELL, 1996, 84 (01) :23-24
[10]   CHARACTERIZATION AND PRIMARY STRUCTURE OF THE POLY(C)-BINDING HETEROGENOUS NUCLEAR RIBONUCLEOPROTEIN COMPLEX K-PROTEIN [J].
MATUNIS, MJ ;
MICHAEL, WM ;
DREYFUSS, G .
MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (01) :164-171
123