Dock GEFs and their therapeutic potential: Neuroprotection and axon regeneration

被引：45

作者：

Namekata, Kazuhiko ^{[1
]}

Kimura, Atsuko ^{[1
]}

Kawamura, Kazuto ^{[1
]}

Harada, Chikako ^{[1
]}

Harada, Takayuki ^{[1
]}

机构：

[1] Tokyo Metropolitan Inst Med Sci, Visual Res Project, Setagaya Ku, Tokyo 1568506, Japan

来源：

PROGRESS IN RETINAL AND EYE RESEARCH | 2014年 / 43卷

关键词：

Dock3; Guanine exchange factors; Glaucoma; Neuroprotection; Axon regeneration; Optic nerve; Retinal ganglion cells; NUCLEOTIDE EXCHANGE FACTOR; RHO-FAMILY GTPASES; PRIMARY-OPEN-ANGLE; NEURAL CELL-DEATH; ADENOMATOUS POLYPOSIS-COLI; ALDRICH-SYNDROME PROTEIN; NMDA RECEPTOR; MOUSE MODEL; OPTIC-NERVE; ALZHEIMERS-DISEASE;

D O I：

10.1016/j.preteyeres.2014.06.005

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The dedicator of cytokinesis (Dock) family is composed of atypical guanine exchange factors (GEFs) that activate the Rho GTPases Rac1 and Cdc42. Rho GTPases are best documented for their roles in actin polymerization and they regulate important cellular functions, including morphogenesis, migration, neuronal development, and cell division and adhesion. To date, 11 Dock family members have been identified and their roles have been reported in diverse contexts. There has been increasing interest in elucidating the roles of Dock proteins in recent years and studies have revealed that they are potential therapeutic targets for various diseases, including glaucoma, Alzheimer's disease, cancer, attention deficit hyperactivity disorder and combined immunodeficiency. Among the Dock proteins, Dock3 is predominantly expressed in the central nervous system and recent studies have revealed that Dock3 plays a role in protecting retinal ganglion cells from neurotoxicity and oxidative stress as well as in promoting optic nerve regeneration. In this review, we discuss the current understanding of the 11 Dock GEFs and their therapeutic potential, with a particular focus on Dock3 as a novel target for the treatment of glaucoma and other neurodegenerative diseases. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：1 / 16

页数：16

共 186 条

[31] Sequence variation in DOCK9 and heterogeneity in bipolar disorder [J].

Detera-Wadleigh, Sevilla D. ;

Liu, Chun-yu ;

Maheshwari, Manjula ;

Cardona, Imer ;

Corona, Winston ;

Akula, Nirmala ;

Steele, C. J. M. ;

Badnerc, Judith A. ;

KundUa, Mukta ;

Kassem, Layla ;

Potash, James B. ;

Gibbs, Richard ;

Gershonc, Elliot S. ;

McMahon, Francis J. .

PSYCHIATRIC GENETICS, 2007, 17 (05) :274-286

[32] Enhanced Expression of NR2B Subunits of NMDA Receptors in the Inherited Glaucomatous DBA/2J Mouse Retina [J].

Dong, Ling-Dan ;

Chen, Jie ;

Li, Fang ;

Gao, Feng ;

Wu, Jihong ;

Miao, Yanying ;

Wang, Zhongfeng .

NEURAL PLASTICITY, 2013, 2013

[33] Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity [J].

Dulak, Austin M. ;

Stojanov, Petar ;

Peng, Shouyong ;

Lawrence, Michael S. ;

Fox, Cameron ;

Stewart, Chip ;

Bandla, Santhoshi ;

Imamura, Yu ;

Schumacher, Steven E. ;

Shefler, Erica ;

McKenna, Aaron ;

Carter, Scott L. ;

Cibulskis, Kristian ;

Sivachenko, Andrey ;

Saksena, Gordon ;

Voet, Douglas ;

Ramos, Alex H. ;

Auclair, Daniel ;

Thompson, Kristin ;

Sougnez, Carrie ;

Onofrio, Robert C. ;

Guiducci, Candace ;

Beroukhim, Rameen ;

Zhou, Zhongren ;

Lin, Lin ;

Lin, Jules ;

Reddy, Rishindra ;

Chang, Andrew ;

Landrenau, Rodney ;

Pennathur, Arjun ;

Ogino, Shuji ;

Luketich, James D. ;

Golub, Todd R. ;

Gabriel, Stacey B. ;

Lander, Eric S. ;

Beer, David G. ;

Godfrey, Tony E. ;

Getz, Gad ;

Bass, Adam J. .

NATURE GENETICS, 2013, 45 (05) :478-U37

[34] The Drosophila DOCK family protein sponge is involved in differentiation of R7 photoreceptor cells [J].

Eguchi, Koichi ;

Yoshioka, Yasuhide ;

Yoshida, Hideki ;

Morishita, Kazushige ;

Miyata, Seiji ;

Hiai, Hiroshi ;

Yamaguchi, Masamitsu .

EXPERIMENTAL CELL RESEARCH, 2013, 319 (14) :2179-2195

[35] An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Sernaphorin 3A signaling [J].

Eickholt, BJ ;

Walsh, FS ;

Doherty, P .

JOURNAL OF CELL BIOLOGY, 2002, 157 (02) :211-217

[36] Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome [J].

Engelhardt, Karin R. ;

McGhee, Sean ;

Winkler, Sabine ;

Sassi, Atfa ;

Woellner, Cristina ;

Lopez-Herrera, Gabriela ;

Chen, Andrew ;

Kim, Hong Sook ;

Lloret, Maria Garcia ;

Schulze, Ilka ;

Ehl, Stephan ;

Thiel, Jens ;

Pfeifer, Dietmar ;

Veelken, Hendrik ;

Niehues, Tim ;

Siepermann, Kathrin ;

Weinspach, Sebastian ;

Reisli, Ismail ;

Keles, Sevgi ;

Genel, Ferah ;

Kutuculer, Necil ;

Camcioglu, Yildiz ;

Somer, Ayper ;

Karakoc-Aydiner, Elif ;

Barlan, Isil ;

Gennery, Andrew ;

Metin, Ayse ;

Degerliyurt, Aydan ;

Pietrogrande, Maria C. ;

Yeganeh, Mehdi ;

Baz, Zeina ;

Al-Tamemi, Salem ;

Klein, Christoph ;

Puck, Jennifer M. ;

Holland, Steven M. ;

McCabe, Edward R. B. ;

Grimbacher, Bodo ;

Chatila, Talal A. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 124 (06) :1289-1302

[37] Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis [J].

Feng, Haizhong ;

Hu, Bo ;

Jarzynka, Michael J. ;

Li, Yanxin ;

Keezer, Susan ;

Johns, Terrance G. ;

Tang, Careen K. ;

Hamilton, Ronald L. ;

Vuori, Kristiina ;

Nishikawa, Ryo ;

Sarkaria, Jann N. ;

Fenton, Tim ;

Cheng, Tao ;

Furnari, Frank B. ;

Cavenee, Webster K. ;

Cheng, Shi-Yuan .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (08) :3018-3023

[38] Activation of Rac1 by Src-dependent phosphorylation of Dock180Y1811 mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans [J].

Feng, Haizhong ;

Hu, Bo ;

Liu, Kun-Wei ;

Li, Yanxin ;

Lu, Xinghua ;

Cheng, Tao ;

Yiin, Jia-Jean ;

Lu, Songjian ;

Keezer, Susan ;

Fenton, Tim ;

Furnari, Frank B. ;

Hamilton, Ronald L. ;

Vuori, Kristiina ;

Sarkaria, Jann N. ;

Nagane, Motoo ;

Nishikawa, Ryo ;

Cavenee, Webster K. ;

Cheng, Shi-Yuan .

JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (12) :4670-4684

[39] Rho kinase inhibition enhances axonal regeneration in the injured CNS [J].

Fournier, AE ;

Takizawa, BT ;

Strittmatter, SM .

JOURNAL OF NEUROSCIENCE, 2003, 23 (04) :1416-1423

[40] Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration [J].

Fukui, Y ;

Hashimoto, O ;

Sanui, T ;

Oono, T ;

Koga, H ;

Abe, M ;

Inayoshi, A ;

Noda, M ;

Oike, M ;

Shirai, T ;

Sasazuki, T .

NATURE, 2001, 412 (6849) :826-831

← 1 2 3 4 5 6 7 8 9 10 →