Calcific Aortic Valve Disease A Consensus Summary From the Alliance of Investigators on Calcific Aortic Valve Disease

被引：272

作者：

Yutzey, Katherine E. ^{[1
]}

Demer, Linda L. ^{[2
,3
,4
]}

Body, Simon C. ^{[5
]}

Huggins, Gordon S. ^{[6
,7
]}

Towler, Dwight A. ^{[8
]}

Giachelli, Cecilia M. ^{[9
]}

Hofmann-Bowman, Marion A. ^{[10
]}

Mortlock, Douglas P. ^{[11
]}

Rogers, Melissa B. ^{[12
]}

Sadeghi, Mehran M. ^{[13
,14
,15
]}

Aikawa, Elena ^{[16
]}

机构：

[1] Cincinnati Childrens Hosp Med Ctr, Inst Heart, Cincinnati, OH 45229 USA

[2] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA

[3] Univ Calif Los Angeles, Dept Physiol, Los Angeles, CA 90024 USA

[4] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA USA

[5] Brigham & Womens Hosp, Ctr Perioperat Genom, Dept Anesthesiol, Boston, MA 02115 USA

[6] Tufts Med Ctr, Ctr Translat Genom, Boston, MA USA

[7] Tufts Univ, Sch Med, Boston, MA 02111 USA

[8] Sanford Burnham Med Res Ctr, Diabet & Obes Res Ctr, Orlando, FL USA

[9] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

[10] Univ Chicago, Dept Med, Cardiol Sect, Chicago, IL 60637 USA

[11] Vanderbilt Univ, Sch Med, Ctr Human Genet Res, Nashville, TN 37212 USA

[12] Rutgers NJ Med Sch, Newark, NJ USA

[13] Yale Univ, Sch Med, Sect Cardiovasc Med, New Haven, CT USA

[14] Yale Univ, Sch Med, Yale Cardiovasc Res Ctr, New Haven, CT USA

[15] VA Connecticut Healthcare Syst, West Haven, CT USA

[16] Harvard Univ, Brigham & Womens Hosp, Ctr Excellence Vasc Biol, Sch Med, Boston, MA 02115 USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2014年 / 34卷 / 11期

关键词：

aortic valve stenosis; calcification; inflammation; POSITRON-EMISSION-TOMOGRAPHY; LOW-DENSITY-LIPOPROTEIN; VASCULAR CALCIFICATION; VALVULAR CALCIFICATION; METABOLIC SYNDROME; STENOSIS; PROGRESSION; HEART; OSTEOPROTEGERIN; INFLAMMATION;

D O I：

10.1161/ATVBAHA.114.302523

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Calcific aortic valve disease (CAVD) is increasingly prevalent worldwide with significant morbidity and mortality. Therapeutic options beyond surgical valve replacement are currently limited. In 2011, the National Heart Lung and Blood Institute assembled a working group on aortic stenosis. This group identified CAVD as an actively regulated disease process in need of further study. As a result, the Alliance of Investigators on CAVD was formed to coordinate and promote CAVD research, with the goals of identifying individuals at risk, developing new therapeutic approaches, and improving diagnostic methods. The group is composed of cardiologists, geneticists, imaging specialists, and basic science researchers. This report reviews the current status of CAVD research and treatment strategies with identification of areas in need of additional investigation for optimal management of this patient population.

引用

页码：2387 / 2393

页数：7

共 70 条

[61] Identification of a Novel Transport-independent Function of PiT1/SLC20A1 in the Regulation of TNF-induced Apoptosis [J].

Salauen, Christine ;

Leroy, Christine ;

Rousseau, Alice ;

Boitez, Valerie ;

Beck, Laurent ;

Friedlander, Gerard .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (45) :34408-34418

[62] Arterial Calcification in Chronic Kidney Disease: Key Roles for Calcium and Phosphate [J].

Shanahan, Catherine M. ;

Crouthamel, Matthew H. ;

Kapustin, Alexander ;

Giachelli, Cecilia M. .

CIRCULATION RESEARCH, 2011, 109 (06) :697-711

[63] Animal Models of Calcific Aortic Valve Disease [J].

Sider, Krista L. ;

Blaser, Mark C. ;

Simmons, Craig A. .

INTERNATIONAL JOURNAL OF INFLAMMATION, 2011, 2011

[64] Elevated osteoprotegerin is associated with all-cause mortality in CKD stage 4 and 5 patients in addition to vascular calcification [J].

Sigrist, Mhairi K. ;

Levin, Adeera ;

Er, Lee ;

McIntyre, Chris W. .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2009, 24 (10) :3157-3162

[65] Clinical factors associated with calcific aortic valve disease [J].

Stewart, BF ;

Siscovick, D ;

Lind, BK ;

Gardin, JM ;

Gottdiener, JS ;

Smith, VE ;

Kitzman, DW ;

Otto, CM .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1997, 29 (03) :630-634

[66] Genetic Associations with Valvular Calcification and Aortic Stenosis [J].

Thanassoulis, George ;

Campbell, Catherine Y. ;

Owens, David S. ;

Smith, J. Gustav ;

Smith, Albert V. ;

Peloso, Gina M. ;

Kerr, Kathleen F. ;

Pechlivanis, Sonali ;

Budoff, Matthew J. ;

Harris, Tamara B. ;

Malhotra, Rajeev ;

O'Brien, Kevin D. ;

Kamstrup, Pia R. ;

Nordestgaard, Borge G. ;

Tybjaerg-Hansen, Anne ;

Allison, Matthew A. ;

Aspelund, Thor ;

Criqui, Michael H. ;

Heckbert, Susan R. ;

Hwang, Shih-Jen ;

Liu, Yongmei ;

Sjogren, Marketa ;

van der Pals, Jesper ;

Kaelsch, Hagen ;

Muehleisen, Thomas W. ;

Noethen, Markus M. ;

Cupples, L. Adrienne ;

Caslake, Muriel ;

Di Angelantonio, Emanuele ;

Danesh, John ;

Rotter, Jerome I. ;

Sigurdsson, Sigurdur ;

Wong, Quenna ;

Erbel, Raimund ;

Kathiresan, Sekar ;

Melander, Olle ;

Gudnason, Vilmundur ;

O'Donnell, Christopher J. ;

Post, Wendy S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (06) :503-512

[67] Osteoprotegerin levels predict mortality in patients with symptomatic aortic stenosis [J].

Ueland, T. ;

Aukrust, P. ;

Dahl, C. P. ;

Husebye, T. ;

Solberg, O. G. ;

Tonnessen, T. ;

Aakhus, S. ;

Gullestad, L. .

JOURNAL OF INTERNAL MEDICINE, 2011, 270 (05) :452-460

[68] Conserved Transcriptional Regulatory Mechanisms in Aortic Valve Development and Disease [J].

Wirrig, Elaine E. ;

Yutzey, Katherine E. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2014, 34 (04) :737-741

[69] Vascular Calcification: An Update on Mechanisms and Challenges in Treatment [J].

Wu, Meiting ;

Rementer, Cameron ;

Giachelli, Cecilia M. .

CALCIFIED TISSUE INTERNATIONAL, 2013, 93 (04) :365-373

[70] miRNA-141 is a novel regulator of BMP-2-mediated calcification in aortic stenosis [J].

Yanagawa, Bobby ;

Lovren, Fina ;

Pan, Yi ;

Garg, Vinay ;

Quan, Adrian ;

Tang, Gilbert ;

Singh, Krishna K. ;

Shukla, Praphulla C. ;

Kalra, Nikhil P. ;

Peterson, Mark D. ;

Verma, Subodh .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2012, 144 (01) :256-+

← 1 2 3 4 5 6 7 →