Calcific Aortic Valve Disease A Consensus Summary From the Alliance of Investigators on Calcific Aortic Valve Disease

被引：272

作者：

Yutzey, Katherine E. ^{[1
]}

Demer, Linda L. ^{[2
,3
,4
]}

Body, Simon C. ^{[5
]}

Huggins, Gordon S. ^{[6
,7
]}

Towler, Dwight A. ^{[8
]}

Giachelli, Cecilia M. ^{[9
]}

Hofmann-Bowman, Marion A. ^{[10
]}

Mortlock, Douglas P. ^{[11
]}

Rogers, Melissa B. ^{[12
]}

Sadeghi, Mehran M. ^{[13
,14
,15
]}

Aikawa, Elena ^{[16
]}

机构：

[1] Cincinnati Childrens Hosp Med Ctr, Inst Heart, Cincinnati, OH 45229 USA

[2] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA

[3] Univ Calif Los Angeles, Dept Physiol, Los Angeles, CA 90024 USA

[4] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA USA

[5] Brigham & Womens Hosp, Ctr Perioperat Genom, Dept Anesthesiol, Boston, MA 02115 USA

[6] Tufts Med Ctr, Ctr Translat Genom, Boston, MA USA

[7] Tufts Univ, Sch Med, Boston, MA 02111 USA

[8] Sanford Burnham Med Res Ctr, Diabet & Obes Res Ctr, Orlando, FL USA

[9] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

[10] Univ Chicago, Dept Med, Cardiol Sect, Chicago, IL 60637 USA

[11] Vanderbilt Univ, Sch Med, Ctr Human Genet Res, Nashville, TN 37212 USA

[12] Rutgers NJ Med Sch, Newark, NJ USA

[13] Yale Univ, Sch Med, Sect Cardiovasc Med, New Haven, CT USA

[14] Yale Univ, Sch Med, Yale Cardiovasc Res Ctr, New Haven, CT USA

[15] VA Connecticut Healthcare Syst, West Haven, CT USA

[16] Harvard Univ, Brigham & Womens Hosp, Ctr Excellence Vasc Biol, Sch Med, Boston, MA 02115 USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2014年 / 34卷 / 11期

关键词：

aortic valve stenosis; calcification; inflammation; POSITRON-EMISSION-TOMOGRAPHY; LOW-DENSITY-LIPOPROTEIN; VASCULAR CALCIFICATION; VALVULAR CALCIFICATION; METABOLIC SYNDROME; STENOSIS; PROGRESSION; HEART; OSTEOPROTEGERIN; INFLAMMATION;

D O I：

10.1161/ATVBAHA.114.302523

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Calcific aortic valve disease (CAVD) is increasingly prevalent worldwide with significant morbidity and mortality. Therapeutic options beyond surgical valve replacement are currently limited. In 2011, the National Heart Lung and Blood Institute assembled a working group on aortic stenosis. This group identified CAVD as an actively regulated disease process in need of further study. As a result, the Alliance of Investigators on CAVD was formed to coordinate and promote CAVD research, with the goals of identifying individuals at risk, developing new therapeutic approaches, and improving diagnostic methods. The group is composed of cardiologists, geneticists, imaging specialists, and basic science researchers. This report reviews the current status of CAVD research and treatment strategies with identification of areas in need of additional investigation for optimal management of this patient population.

引用

页码：2387 / 2393

页数：7

共 70 条

[11] Interactions between adrenal- regulatory and calcium- regulatory hormones in human health [J].

Brown, Jenifer M. ;

Vaidya, Anand .

CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY, 2014, 21 (03) :193-201

[12] Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling [J].

Byon, Chang Hyun ;

Javed, Amjad ;

Dai, Qun ;

Kappes, John C. ;

Clemens, Thomas L. ;

Darley-Usmar, Victor M. ;

McDonald, Jay M. ;

Chen, Yabing .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (22) :15319-15327

[13] Human degenerative valve disease is associated with up-regulation of low-density lipoprotein receptor-related protein 5 receptor-mediated bone formation [J].

Caira, FC ;

Stock, SR ;

Gleason, TG ;

McGee, EC ;

Huang, J ;

Bonow, RO ;

Spelsberg, TC ;

McCarthy, PM ;

Rahimtoola, SH ;

Rajamannan, NM .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 47 (08) :1707-1712

[14] Effect of Lipid Lowering With Rosuvastatin on Progression of Aortic Stenosis Results of the Aortic Stenosis Progression Observation: Measuring Effects of Rosuvastatin (ASTRONOMER) Trial [J].

Chan, Kwan Leung ;

Teo, Koon ;

Dumesnil, Jean G. ;

Ni, Andy ;

Tam, James .

CIRCULATION, 2010, 121 (02) :306-U247

[15] Differential activation of valvulogenic, chondrogenic, and osteogenic pathways in mouse models of myxomatous and calcific aortic valve disease [J].

Cheek, Jonathan D. ;

Wirrig, Elaine E. ;

Alfieri, Christina M. ;

James, Jeanne F. ;

Yutzey, Katherine E. .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2012, 52 (03) :689-700

[16] Activation of Vascular Smooth Muscle Parathyroid Hormone Receptor Inhibits Wnt/β-Catenin Signaling and Aortic Fibrosis in Diabetic Arteriosclerosis [J].

Cheng, Su-Li ;

Shao, Jian-Su ;

Halstead, Linda R. ;

Distelhorst, Kathryn ;

Sierra, Oscar ;

Towler, Dwight A. .

CIRCULATION RESEARCH, 2010, 107 (02) :271-U222

[17] Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients [J].

Chertow, GM ;

Burke, SK ;

Raggi, P .

KIDNEY INTERNATIONAL, 2002, 62 (01) :245-252

[18] Biomechanical implications of the congenital bicuspid aortic valve: A finite element study of aortic root function from in vivo data [J].

Conti, Carlo A. ;

Della Corte, Alessandro ;

Votta, Emiliano ;

Del Viscovo, Luca ;

Bancone, Ciro ;

De Santo, Luca S. ;

Redaelli, Alberto .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2010, 140 (04) :890-U203

[19] Transcatheter Aortic Valve Replacement: Current Status and Future Directions [J].

Desai, Chintan S. ;

Roselli, Eric E. ;

Svensson, Lars G. ;

Bonow, Robert O. .

SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY, 2013, 25 (03) :193-196

[20] Assessment of Valvular Calcification and Inflammation by Positron Emission Tomography in Patients With Aortic Stenosis [J].

Dweck, Marc Richard ;

Jones, Charlotte ;

Joshi, Nikhil V. ;

Fletcher, Alison M. ;

Richardson, Hamish ;

White, Audrey ;

Marsden, Mark ;

Pessotto, Renzo ;

Clark, John C. ;

Wallace, William A. ;

Salter, Donald M. ;

McKillop, Graham ;

van Beek, Edwin J. R. ;

Boon, Nicholas A. ;

Rudd, James H. F. ;

Newby, David E. .

CIRCULATION, 2012, 125 (01) :76-U424

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