Chronic Kidney Disease and Stroke

被引：53

作者：

El Husseini, Nada

Kaskar, Omran

Goldstein, Larry B.

机构：

[1] Duke Univ, Med Ctr, Dept Neurol, Durham, NC USA

[2] Wake Forest Univ, Baptist Med Ctr, Dept Neurol, Winston Salem, NC 27157 USA

来源：

ADVANCES IN CHRONIC KIDNEY DISEASE | 2014年 / 21卷 / 06期

关键词：

Chronic kidney disease; Stroke; Thrombolysis; Alteplase; Stroke prevention; GLOMERULAR-FILTRATION-RATE; ATRIAL-FIBRILLATION PATIENTS; RISK-FACTOR; RENAL DYSFUNCTION; ISCHEMIC-STROKE; INTRACRANIAL HEMORRHAGE; HEMODIALYSIS-PATIENTS; CLINICAL-OUTCOMES; WARFARIN; PREVENTION;

D O I：

10.1053/j.ackd.2014.09.001

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic kidney disease (CKD) is associated with an increased risk of both ischemic and hemorrhagic stroke. In addition to shared risk factors, this higher cerebrovascular risk is mediated by several CKD-associated mechanisms including platelet dysfunction, coagulation disorders, endothelial dysfunction, inflammation, and increased risk of atrial fibrillation. CKD can also modify the effect of treatments used in acute stroke and in secondary stroke prevention. We review the epidemiology and pathophysiology that link CKD and stroke and the impact of CKD on stroke outcomes. Interdisciplinary collaboration between nephrologists, pharmacists, hematologists, nutrition therapists, primary care physicians, and neurologists in providing care to these subjects may potentially improve outcomes. (C) 2014 by the National Kidney Foundation, Inc. All rights reserved.

引用

页码：500 / 508

页数：9

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