Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid

被引：30

作者：

Arlia-Ciommo, Anthony ^{[1
]}

Piano, Amanda ^{[1
]}

Svistkova, Veronika ^{[1
]}

Mohtashami, Sadaf ^{[1
]}

Titorenko, Vladimir I. ^{[1
]}

机构：

[1] Concordia Univ, Dept Biol, Montreal, PQ H4B 1R6, Canada

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2014年 / 15卷 / 09期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

bioactive lipids; lipid metabolism; lipidomics; bile acids; aging and age-related diseases; cancer; anti-aging and anti-tumor therapeutic agents; endoplasmic reticulum; mitochondria; cell death; CHRONOLOGICAL LIFE-SPAN; CHEMICAL GENETIC SCREEN; PROTEIN-KINASE-A; CYCLASE TYPE 5; CALORIE RESTRICTION; C.-ELEGANS; DIETARY RESTRICTION; ENDOPLASMIC-RETICULUM; CELLULAR SENESCENCE; LIPID-METABOLISM;

D O I：

10.3390/ijms150916522

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bile acids are cholesterol-derived bioactive lipids that play essential roles in the maintenance of a heathy lifespan. These amphipathic molecules with detergent-like properties display numerous beneficial effects on various longevity- and healthspan-promoting processes in evolutionarily distant organisms. Recent studies revealed that lithocholic bile acid not only causes a considerable lifespan extension in yeast, but also exhibits a substantial cytotoxic effect in cultured cancer cells derived from different tissues and organisms. The molecular and cellular mechanisms underlying the robust anti-aging and anti-tumor effects of lithocholic acid have emerged. This review summarizes the current knowledge of these mechanisms, outlines the most important unanswered questions and suggests directions for future research.

引用

页码：16522 / 16543

页数：22

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