Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid

被引：28
作者：
Arlia-Ciommo, Anthony [1 ]
Piano, Amanda [1 ]
Svistkova, Veronika [1 ]
Mohtashami, Sadaf [1 ]
Titorenko, Vladimir I. [1 ]
机构：
[1] Concordia Univ, Dept Biol, Montreal, PQ H4B 1R6, Canada
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2014年 / 15卷 / 09期
基金：
加拿大健康研究院; 加拿大自然科学与工程研究理事会;
关键词：
bioactive lipids; lipid metabolism; lipidomics; bile acids; aging and age-related diseases; cancer; anti-aging and anti-tumor therapeutic agents; endoplasmic reticulum; mitochondria; cell death; CHRONOLOGICAL LIFE-SPAN; CHEMICAL GENETIC SCREEN; PROTEIN-KINASE-A; CYCLASE TYPE 5; CALORIE RESTRICTION; C.-ELEGANS; DIETARY RESTRICTION; ENDOPLASMIC-RETICULUM; CELLULAR SENESCENCE; LIPID-METABOLISM;
D O I：
10.3390/ijms150916522
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bile acids are cholesterol-derived bioactive lipids that play essential roles in the maintenance of a heathy lifespan. These amphipathic molecules with detergent-like properties display numerous beneficial effects on various longevity- and healthspan-promoting processes in evolutionarily distant organisms. Recent studies revealed that lithocholic bile acid not only causes a considerable lifespan extension in yeast, but also exhibits a substantial cytotoxic effect in cultured cancer cells derived from different tissues and organisms. The molecular and cellular mechanisms underlying the robust anti-aging and anti-tumor effects of lithocholic acid have emerged. This review summarizes the current knowledge of these mechanisms, outlines the most important unanswered questions and suggests directions for future research.
引用
收藏
页码：16522 / 16543
页数：22
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