Decreased glomerular filtration as the primary factor of elevated circulating suPAR levels in focal segmental glomerulosclerosis

被引：28

作者：

Harita, Yutaka ^{[1
]}

Ishizuka, Kiyonobu ^{[2
]}

Tanego, Atsushi ^{[3
]}

Sugawara, Noriko ^{[2
]}

Chikamoto, Hiroko ^{[2
]}

Akioka, Yuko ^{[2
]}

Tsurumi, Haruko ^{[1
]}

Miura, Kenichiro ^{[1
]}

Gotoh, Yoshimitsu ^{[4
]}

Tsujita, Makoto ^{[5
]}

Yamamoto, Takayuki ^{[5
]}

Horike, Keiji ^{[5
]}

Takeda, Asami ^{[5
]}

Oka, Akira ^{[1
]}

Igarashi, Takashi ^{[1
]}

Hattori, Motoshi ^{[2
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Pediat, Bunkyo Ku, Tokyo 1138655, Japan

[2] Tokyo Womens Med Univ, Dept Pediat Nephrol, Tokyo, Japan

[3] Kitasato Univ, Sch Pharmaceut Sci, Div Biochem, Minato Ku, Tokyo 1088641, Japan

[4] Japanese Red Cross Nagoya Daini Hosp, Dept Pediat Nephrol, Nagoya, Aichi, Japan

[5] Japanese Red Cross Nagoya Daini Hosp, Kidney Dis Ctr, Nagoya, Aichi, Japan

来源：

PEDIATRIC NEPHROLOGY | 2014年 / 29卷 / 09期

关键词：

Soluble urokinase receptor; Focal segmental glomerulosclerosis; Post-transplant recurrence; SOLUBLE UROKINASE RECEPTOR; PLASMINOGEN-ACTIVATOR; NEPHROTIC SYNDROME; JAPANESE CHILDREN; UPA/SUPAR SYSTEM; DISEASE;

D O I：

10.1007/s00467-014-2808-5

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Circulating factor(s) has been thought to be the underlying cause of focal segmental glomerulosclerosis (FSGS), and recent studies foster this idea by demonstrating increased soluble urokinase receptor (suPAR) levels in the serum of FSGS patients. To explore the possible contribution of suPAR in FSGS pathogenesis, we analyzed serum suPAR levels in 17 patients with FSGS and compared them with those in patients with steroid-sensitive nephrotic syndrome, chronic glomerulonephritis, or non-glomerular kidney diseases. Serum suPAR levels in patients with FSGS were higher than those in patients with steroid-sensitive nephrotic syndrome or chronic glomerulonephritis, but not higher than those in patients with non-glomerular kidney diseases. suPAR levels negatively correlate with estimated glomerular filtration rate and were decreased after renal transplantation in patients with FSGS as well as in those with non-glomerular kidney diseases. Furthermore, 6 FSGS patients with post-transplant recurrence demonstrated that suPAR levels were not high during the recurrence. Based on our results, elevated suPAR levels in FSGS patients were attributed mainly to decreased glomerular filtration. These data warrant further analysis for involvement of possible circulating factor(s) in FSGS pathogenesis.

引用

页码：1553 / 1560

页数：8

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