NOE pumping. 2. A high-throughput method to determine compounds with binding affinity to macromolecules by NMR

被引：107

作者：

Chen, AD ^{[1
]}

Shapiro, MJ ^{[1
]}

机构：

[1] Novartis Inst Biomed Res, Summit, NJ 07901 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2000年 / 122卷 / 02期

关键词：

D O I：

10.1021/ja992588j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：414 / 415

页数：2

共 18 条

[1]

AKI H, 1992, CHEM PHARM BULL, V40, P1553

[2] A HIGH-TEMPERATURE SUPERCONDUCTING RECEIVER FOR NUCLEAR-MAGNETIC-RESONANCE MICROSCOPY [J].

BLACK, RD ;

EARLY, TA ;

ROEMER, PB ;

MUELLER, OM ;

MOGROCAMPERO, A ;

TURNER, LG ;

JOHNSON, GA .

SCIENCE, 1993, 259 (5096) :793-795

[3] EFFECTS OF DIFFUSION ON FREE PRECESSION IN NUCLEAR MAGNETIC RESONANCE EXPERIMENTS [J].

CARR, HY ;

PURCELL, EM .

PHYSICAL REVIEW, 1954, 94 (03) :630-638

[4] NOE pumping: A novel NMR technique for identification of compounds with binding affinity to macromolecules [J].

Chen, A ;

Shapiro, MJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (39) :10258-10259

[5] THEORY OF THE TIME-DEPENDENT TRANSFERRED NUCLEAR OVERHAUSER EFFECT - APPLICATIONS TO STRUCTURAL-ANALYSIS OF LIGAND PROTEIN COMPLEXES IN SOLUTION [J].

CLORE, GM ;

GRONENBORN, AM .

JOURNAL OF MAGNETIC RESONANCE, 1983, 53 (03) :423-442

[6] THEORY AND APPLICATIONS OF THE TRANSFERRED NUCLEAR OVERHAUSER EFFECT TO THE STUDY OF THE CONFORMATIONS OF SMALL LIGANDS BOUND TO PROTEINS [J].

CLORE, GM ;

GRONENBORN, AM .

JOURNAL OF MAGNETIC RESONANCE, 1982, 48 (03) :402-417

[7] One-dimensional relaxation- and diffusion-edited NMR methods for screening compounds that bind to macromolecules [J].

Hajduk, PJ ;

Olejniczak, ET ;

Fesik, SW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (50) :12257-12261

[8] High-throughput nuclear magnetic resonance-based screening [J].

Hajduk, PJ ;

Gerfin, T ;

Boehlen, JM ;

Häberli, M ;

Marek, D ;

Fesik, SW .

JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (13) :2315-2317

[9] Detecting binding affinity to immobilized receptor proteins in compound libraries by HR-MAS STD NMR [J].

Klein, J ;

Meinecke, R ;

Mayer, M ;

Meyer, B .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (22) :5336-5337

[10] Diffusion-edited NMR-affinity NMR for direct observation of molecular interactions [J].

Lin, MF ;

Shapiro, MJ ;

Wareing, JR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (22) :5249-5250

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