The aim of this study was to examine the effects of changes in maximal aerobic (MAS) and sprinting (MSS) speeds and the anaerobic reserve (ASR) on repeated-sprint performance. Two hundred and seventy highly-trained soccer players (14.5 +/- 1.6 year) completed three times per season (over 5 years) a maximal incremental running test to approach MAS, a 40-m sprint with 10-m splits to assess MSS and a repeated-sprint test (10 x 30-m sprints), where best (RSb) and mean (RSm) sprint times, and percentage of speed decrement (%Dec) were calculated. ASR was calculated as MSS-MAS. While Delta RSb were related to Delta MSS and Delta body mass (r(2) = 0.42, 90% CL[0.34;0.49] for the overall multiple regression, n = 334),.RSm was also correlated with.MAS and.sum of 7 skinfolds (r(2) = 0.43 [0.35;0.50], n = 334). There was a small and positive association between Delta% Dec and Delta MAS (r(2) = 0.02 [-0.07;0.11], n = 334). Substantial Delta MSS and Delta MAS had a predictive value of 70 and 55% for.RSm, respectively. Finally, Delta ASR per se was not predictive of Delta RSm (Cohen's = +0.8 to -0.3 with increased ASR), but the greater magnitude of Delta RSm improvement was observed when MSS, MAS and ASR increased together (0.8 vs. + 0.4 with ASR increased vs. not, additionally to MSS and MAS). Low-cost field tests aimed at assessing maximal sprinting and aerobic speeds can be used to monitor Delta RS performance.