Prostate cancer and therapeutic challenges

被引：7
作者：
Hawsawi, Yousef MohammedRabaa [1 ,2 ]
Zailaie, Samar Abdullah [1 ]
Oyouni, Atif Abdulwahab A. [3 ]
Alzahrani, Othman Rashed [3 ]
Alamer, Osama Mohamed [4 ]
Aljohani, Saad Ali S. [5 ]
机构：
[1] King Faisal Specialist Hosp & Res Ctr, Jeddah Satellite Lab, Saudi Human Genome Program, Res Ctr, MBC J04,POB 40047, Jeddah 21499, Saudi Arabia
[2] Al Faisal Univ, Coll Med, POB 50927, Riyadh 11533, Saudi Arabia
[3] Univ Tabuk, Fac Sci, Dept Biol, Tabuk, Saudi Arabia
[4] Univ Tabuk, Fac Appl Med Sci, Dept Med Lab Technol, Tabuk, Saudi Arabia
[5] Al Rayan Coll, Fac Med, Dept Basic Med Sci, Al Munawarrah, Saudi Arabia
来源：
JOURNAL OF BIOLOGICAL RESEARCH-THESSALONIKI | 2020年 / 27卷 / 01期
关键词：
Prostate cancer; Androgens; Androgen receptor; Anti-androgen therapy; Heat-shock protein; HEAT-SHOCK PROTEINS; ANDROGEN RECEPTOR MUTATIONS; STEROID-INDUCED APOPTOSIS; ANTITUMOR-ACTIVITY; BREAST; INHIBITORS; GROWTH; OVEREXPRESSION; BICALUTAMIDE; RESISTANCE;
D O I：
10.1186/s40709-020-00128-z
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Prostate cancer (PC) is the most prevalent type of cancer in men worldwide. In Saudi Arabia, the rate of PC is increasing annually. The sex steroid hormones androgens and their receptors have critical roles in PC development and progression. Additionally, apoptosis-related proteins such as heat-shock proteins are vital molecules in PC development. Steroid hormone-deprivation therapies remain the essential treatment for patients with metastatic PCs; however, acquired resistance to hormone deprivation and the transition to PC androgen independence is a major health obstacle. In this review, we aim to detail the roles of androgens, androgen receptors and sex steroid hormones in inducing apoptosis in PC.
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页数：7
相关论文
共 63 条
  • [1] AKAKURA K, 1993, CANCER, V71, P2782, DOI 10.1002/1097-0142(19930501)71:9<2782::AID-CNCR2820710916>3.0.CO
  • [2] 2-Z
  • [3] Heat shock and other apoptosis-related proteins as therapeutic targets in prostate cancer
    Albany, Costantine
    Hahn, Noah M.
    [J]. ASIAN JOURNAL OF ANDROLOGY, 2014, 16 (03) : 359 - 363
  • [4] Impact of Comorbidity on Survival Among Men With Localized Prostate Cancer
    Albertsen, Peter C.
    Moore, Dirk F.
    Shih, Weichung
    Lin, Yong
    Li, Hui
    Lu-Yao, Grace L.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (10) : 1335 - 1341
  • [5] Alghamidi Ibrahim G, 2014, Hematol Oncol Stem Cell Ther, V7, P18, DOI 10.1016/j.hemonc.2013.10.001
  • [6] Validation of Novel Biomarkers for Prostate Cancer Progression by the Combination of Bioinformatics, Clinical and Functional Studies
    Alinezhad, Saeid
    Vaananen, Riina-Minna
    Mattsson, Jesse
    Li, Yifeng
    Tallgren, Terhi
    Ochoa, Natalia Tong
    Bjartell, Anders
    Akerfelt, Malin
    Taimen, Pekka
    Bostrom, Peter J.
    Pettersson, Kim
    Nees, Matthias
    [J]. PLOS ONE, 2016, 11 (05):
  • [7] SELECTIVE RETENTION OF DIHYDROTESTO-STERONE BY PROSTATIC NUCLEI
    ANDERSON, KM
    LIAO, S
    [J]. NATURE, 1968, 219 (5151) : 277 - &
  • [8] Prostate cancer: Prognostic significance of the association of heterogeneous nuclear ribonucleoprotein K and androgen receptor expression
    Barboro, Paola
    Salvi, Sandra
    Rubagotti, Alessandra
    Boccardo, Simona
    Spina, Bruno
    Truini, Mauro
    Carmignani, Giorgio
    Introini, Carlo
    Ferrari, Nicoletta
    Boccardo, Francesco
    Balbi, Cecilia
    [J]. INTERNATIONAL JOURNAL OF ONCOLOGY, 2014, 44 (05) : 1589 - 1598
  • [9] Bostwick DG, 2000, ARCH PATHOL LAB MED, V124, P995
  • [10] Targeting Heat Shock Protein 90 with Non-Quinone Inhibitors: A Novel Chemotherapeutic Approach in Human Hepatocellular Carcinoma
    Breinig, Marco
    Caldas-Lopes, Eloisi
    Goeppert, Benjamin
    Malz, Mona
    Rieker, Ralf
    Bergmann, Frank
    Schirmacher, Peter
    Mayer, Matthias
    Chiosis, Gabriela
    Kern, Michael Andre
    [J]. HEPATOLOGY, 2009, 50 (01) : 102 - 112
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