Enatioselective organocatalytic synthesis of highly functionalized tetrahydrothiophenes by a Michael-aldol cascade reaction

被引：37

作者：

Luo, Guangshun ^{[1
]}

Zhang, Shilei ^{[1
]}

Duan, Wenhu ^{[1
,2
]}

Wang, Wei ^{[1
,2
,3
]}

机构：

[1] E China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut Sci, Shanghai 200237, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

[3] Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 24期

基金：

美国国家科学基金会;

关键词：

Cascade reactions; Michael-aldol; Organocatalysis; Tetrahydrothiophenes; DIPHENYLPROLINOL SILYL ETHER; ONE-POT SYNTHESIS; DOMINO REACTIONS; STEREOCONTROLLED SYNTHESIS; CONSTRUCTION; CATALYST; HENRY;

D O I：

10.1016/j.tetlet.2009.03.218

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A catalytic asymmetric Michael-aldol cascade process for efficient synthesis of trisubstituted tetrahydrothiophenes is reported with high enantio- and diastereo-selectivities. Notably, three consecutive stereogenic centers including one chiral quaternary carbon center are efficiently created in the 'one-pot' operation. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2946 / 2948

页数：3

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