Nitric Oxide, Oxidative Stress, and p66Shc Interplay in Diabetic Endothelial Dysfunction

被引：95

作者：

Magenta, Alessandra ^{[1
]}

Greco, Simona ^{[2
]}

Capogrossi, Maurizio C. ^{[1
]}

Gaetano, Carlo ^{[3
]}

Martelli, Fabio ^{[2
]}

机构：

[1] Ist Dermopat Immacolata IRCCS, Vasc Pathol Lab, I-00167 Rome, Italy

[2] Policlin San Donato IRCCS, Mol Cardiol Lab, I-20097 Milan, Italy

[3] Goethe Univ Frankfurt, Div Cardiovasc Epigenet, Dept Cardiol, Internal Med Clin 3, D-60590 Frankfurt, Germany

来源：

BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷

关键词：

LIFE-SPAN DETERMINANT; INFLAMMATORY GENE-EXPRESSION; FOXO TRANSCRIPTION FACTORS; SMOOTH-MUSCLE-CELLS; C-REACTIVE PROTEIN; NF-KAPPA-B; INSULIN-RESISTANCE; ADAPTER PROTEIN; SKELETAL-MUSCLE; MATERNAL-HYPERCHOLESTEROLEMIA;

D O I：

10.1155/2014/193095

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Increased oxidative stress and reduced nitric oxide (NO) bioavailability play a causal role in endothelial cell dysfunction occurring in the vasculature of diabetic patients. In this review, we summarized the molecular mechanisms underpinning diabetic endothelial and vascular dysfunction. In particular, we focused our attention on the complex interplay existing among NO, reactive oxygen species (ROS), and one crucial regulator of intracellular ROS production, p66(Shc) protein.

引用

页数：16

共 50 条

[1] The Role of p66shc in Oxidative Stress and Apoptosis
Galimov, E. R.
ACTA NATURAE, 2010, 2 (04): : 44 - 51
[2] Involvement of p66Shc in TNFα-Induced Endothelial Dysfunction
Orlando, Maura R.
Laviola, Luigi
Tortosa, Federica
Incalza, Maria Angela
Melchiorre, Mariangela
Leonardini, Anna
Perrini, Sebastio
Natalicchio, Annalisa
Giorgino, Francesco
DIABETES, 2010, 59 : A241 - A241
[3] The implication of p66shc in oxidative stress induced by deltamethrin
Ding, Ruqian
Cao, Zongfu
Wang, Yihan
Gao, Xiaobo
Luo, Haiyan
Zhang, Changyong
Ma, Shuangcheng
Ma, Xu
Jin, Hongyu
Lu, Cailing
CHEMICO-BIOLOGICAL INTERACTIONS, 2017, 278 : 162 - 169
[4] p66Shc:: at the crossroad of oxidative stress and the genetics of aging
Purdom, S
Chen, QM
TRENDS IN MOLECULAR MEDICINE, 2003, 9 (05) : 206 - 210
[5] Genetic deletion of p66Shc adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress
Camici, Giovanni G.
Schiavoni, Marzia
Francia, Pietro
Bachschmid, Markus
Martin-Padura, Ines
Hersberger, Martin
Tanner, Felix C.
Pelicci, PierGiuseppe
Volpe, Massimo
Anversa, Piero
Luescher, Thomas F.
Cosentino, Francesco
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (12) : 5217 - 5222
[6] P66Shc and vascular endothelial function
Kumar, Santosh
BIOSCIENCE REPORTS, 2019, 39
[7] Involvement of p66Shc in TNF-alpha-induced endothelial dysfunction
Orlando, M. R.
Laviola, L.
Tortosa, F.
Incalza, M.
Leonardini, A.
Melchiorre, M.
Labarbuta, R.
Perrini, S.
Natalicchio, A.
Giorgino, F.
DIABETOLOGIA, 2010, 53
[8] Role of P66SHC in aldosterone induced endothelial dysfunction and vascular remodeling
Battistoni, Allegera
Ucci, Sarassunta
Nicoletti, Carmine
Reale, Simone
Montezano, Augusto C.
Falco, Raffaele
Filippini, Antonio
Volpe, Massimo
Touyz, Rhian M.
Savoia, Carmine
EUROPEAN HEART JOURNAL SUPPLEMENTS, 2019, 21 (0J) : J119 - J119
[9] Tat-Mediated p66shc Transduction Decreased Phosphorylation of Endothelial Nitric Oxide Synthase in Endothelial Cells
Lee, Sang Ki
Lee, Ji Young
Joo, Hee Kyoung
Cho, Eun Jung
Kim, Cuk Seong
Lee, Sang Do
Park, Jin Bong
Jeon, Byeong Hwa
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2012, 16 (03): : 199 - 204
[10] Cardiac mitochondrial dysfunction during hyperglycemia-The role of oxidative stress and p66Shc signaling
Diogo, Catia V.
Suski, Jan M.
Lebiedzinska, Magdalena
Karkucinska-Wieckowska, Agnieszka
Wojtala, Aleksandra
Pronicki, Maciej
Duszynski, Jerzy
Pinton, Paolo
Portincasa, Piero
Oliveira, Paulo J.
Wieckowski, Mariusz R.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2013, 45 (01): : 114 - 122

← 1 2 3 4 5 →