Solvent-, and Catalyst-free Acylation of Anilines with Meldrum's Acids: ANeat Access to Anilides

被引：10

作者：

Li, Jiang-Sheng ^{[1
]}

Da, Yu-Dong ^{[1
]}

Chen, Guo-Qin ^{[1
]}

Yang, Qian ^{[1
]}

Li, Zhi-Wei ^{[1
]}

Yang, Fan ^{[1
]}

Huang, Peng-Mian ^{[1
]}

机构：

[1] Changsha Univ Sci & Technol, Sch Chem & Biol Engn, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Hunan, Peoples R China

来源：

CHEMISTRYSELECT | 2017年 / 2卷 / 05期

关键词：

acylation; amide formation; anilides; green chemistry; Meldrum's acids; AMIDE BOND FORMATION; METAL-FREE SYNTHESIS; INTRAMOLECULAR O-ARYLATION; C-H; CARBOXYLIC-ACIDS; 2-ARYL BENZOXAZOLES; SECONDARY AMIDES; DIRECT AMIDATION; EFFICIENT METHOD; FACILE SYNTHESIS;

D O I：

10.1002/slct.201601965

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and neat procedure for N-acylation of anilines has been developed using 5-(un)substituted Meldrum's acids as acyl surrogates under neutral conditions in excellent yields. This protocol features a solvent-free and catalyst-free acylation process, and enables facile access to a vast array of structurally versatile sec-and tert-anilides.

引用

收藏

页码：1770 / 1773

页数：4

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