Animal to human translation: a systematic scoping review of reported concordance rates

被引:189
作者
Leenaars, Cathalijn H. C. [1 ,2 ,3 ]
Kouwenaar, Carien [1 ]
Stafleu, Frans R. [1 ]
Bleich, Andre [2 ]
Ritskes-Hoitinga, Merel [3 ]
De Vries, Rob B. M. [3 ]
Meijboom, Franck L. B. [1 ]
机构
[1] Univ Utrecht, Dept Anim Sci & Soc, Fac Vet Sci, Utrecht, Netherlands
[2] Hannover Med Sch, Inst Lab Anim Sci, Hannover, Germany
[3] Radboud Univ Nijmegen, Med Ctr, SYRCLE, Dept Hlth Evidence,Sect HTA,Radboud Inst Hlth Sci, Nijmegen, Netherlands
关键词
Translation; Prediction; Systematic review; INTRAVENOUS PHARMACOKINETIC PARAMETERS; ADVERSE DRUG-REACTIONS; PREDICTIVE-VALUE; QUALITATIVE EVALUATION; ORAL BIOAVAILABILITY; TOXICITY; DOG; PHARMACEUTICALS; EXTRAPOLATION; ATTRITION;
D O I
10.1186/s12967-019-1976-2
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
BackgroundDrug development is currently hampered by high attrition rates; many developed treatments fail during clinical testing. Part of the attrition may be due to low animal-to-human translational success rates; so-called translational failure. As far as we know, no systematic overview of published translational success rates exists.Systematic scoping reviewThe following research question was examined: What is the observed range of the animal-to-human translational success (and failure) rates within the currently available empirical evidence?. We searched PubMed and Embase on 16 October 2017. We included reviews and all other types of umbrella-studies of meta-data quantitatively comparing the translational results of studies including at least two species with one being human. We supplemented our database searches with additional strategies. All abstracts and full-text papers were screened by two independent reviewers. Our scoping review comprises 121 references, with various units of measurement: compound or intervention (k=104), study/experiment (k=10), and symptom or event (k=7). Diagnostic statistics corresponded with binary and continuous definitions of successful translation. Binary definitions comprise percentages below twofold error, percentages accurately predicted, and predictive values. Quantitative definitions comprise correlation/regression (r(2)) and meta-analyses (percentage overlap of 95% confidence intervals). Translational success rates ranged from 0 to 100%.ConclusionThe wide range of translational success rates observed in our study might indicate that translational success is unpredictable; i.e. it might be unclear upfront if the results of primary animal studies will contribute to translational knowledge. However, the risk of bias of the included studies was high, and much of the included evidence is old, while newer models have become available. Therefore, the reliability of the cumulative evidence from current papers on this topic is insufficient. Further in-depth umbrella-studies of translational success rates are still warranted. These are needed to evaluate the probabilistic evidence for predictivity of animal studies for the human situation more reliably, and to determine which factors affect this process.
引用
收藏
页数:22
相关论文
共 50 条
[41]   Clinical characteristics of BRASH syndrome: Systematic scoping review [J].
Shah, Parthav ;
Gozun, Maan ;
Keitoku, Koichi ;
Kimura, Nobuhiko ;
Yeo, Jihun ;
Czech, Torrey ;
Nishimura, Yoshito .
EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2022, 103 :57-61
[42]   A systematic scoping review of medicine availability and affordability in Africa [J].
Jeff Lane ;
Hilma Nakambale ;
Asha Kadakia ;
Yoswa Dambisya ;
Andy Stergachis ;
Walter Denis Odoch .
BMC Health Services Research, 24
[43]   Self-managed abortion: A systematic scoping review [J].
Moseson, Heidi ;
Herold, Stephanie ;
Filippa, Sofia ;
Barr-Walker, Jill ;
Baum, Sarah E. ;
Gerdts, Caitlin .
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY, 2020, 63 :87-110
[44]   Health promotion in schools: a scoping review of systematic reviews [J].
Chilton, Roy ;
Pearson, Mark ;
Anderson, Rob .
HEALTH EDUCATION, 2015, 115 (3-4) :357-376
[45]   Reporting characteristics of systematic reviews in Psychology: A scoping review [J].
Steil, Andrea Valeria ;
Dias, Natalia Martins ;
Lopes, Fernanda Machado ;
da Silva, Mariana Luiza Becker ;
Bousfield, Andrea Barbara da Silva ;
De Luca Canto, Graziela .
JOURNAL OF HEALTH PSYCHOLOGY, 2022, 27 (13) :2964-2981
[46]   Artificial intelligence in outcomes research: a systematic scoping review [J].
Graili, Pooyeh ;
Ieraci, Luciano ;
Hosseinkhah, Nazanin ;
Argent-Katwala, Mary .
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH, 2021, 21 (04) :601-623
[47]   Citation tracking for systematic literature searching: A scoping review [J].
Hirt, Julian ;
Nordhausen, Thomas ;
Appenzeller-Herzog, Christian ;
Ewald, Hannah .
RESEARCH SYNTHESIS METHODS, 2023, 14 (03) :563-579
[48]   A systematic scoping review of medicine availability and affordability in Africa [J].
Lane, Jeff ;
Nakambale, Hilma ;
Kadakia, Asha ;
Dambisya, Yoswa ;
Stergachis, Andy ;
Odoch, Walter Denis .
BMC HEALTH SERVICES RESEARCH, 2024, 24 (01)
[49]   The use of animal-assisted practices as a nursing intervention: A systematic review [J].
Demiralay, Seyma ;
Keser, Ilkay ;
Caynak, Sibel .
JOURNAL OF PSYCHIATRIC NURSING, 2020, 11 (03) :239-250
[50]   Systematic Review: Rates and Determinants of Relapse to Alcohol: A Systematic Review of Indian Studies [J].
Sarkar, Siddharth ;
Tom, Ashlyn ;
Das, Sauvik ;
Bharadwaj, Balaji ;
Ghosh, Abhishek .
JOURNAL OF MENTAL HEALTH AND HUMAN BEHAVIOUR, 2022, 27 (01) :8-18