Tryptophan-deficient diet increases the neurochemical and behavioral response to amphetamine

被引：14
作者：
Carta, Manolo [1 ]
Fadda, Fabio [1 ]
Stancampiano, Roberto [1 ]
机构：
[1] Univ Cagliari, Dept Sci Appl Biosyst, Sect Physiol & Human Nutr, I-09124 Cagliari, Italy
来源：
BRAIN RESEARCH | 2006年 / 1094卷
关键词：
tryptophan; striatum; nucleus accumbens; serotonin; dopamine release; locomotor activity;
D O I：
10.1016/j.brainres.2006.03.118
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The present study examined the effects of a tryptophan-deficient diet on behavioral and neurochemical response to amphetamine. A tryptophan-deficient diet (14 days) decreased striatal serotonin and 5-hydroxyindolacetic acid content in rats. Under the latter conditions, amphetamine increased dopamine efflux in striatum and nucleus accumbens and produced a greater increase in motor activity when compared to controls. These results indicate how response to psychostimulants might be altered in the presence of a tryptophan-deficient diet. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：86 / 91
页数：6
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