Biopolymer-based strategies in the design of smart medical devices and artificial organs

被引：55
|
作者：
Altomare, Lina [1 ,2 ]
Bonetti, Lorenzo [1 ,2 ]
Campiglio, Chiara E. [1 ,2 ]
De Nardo, Luigi [1 ,2 ]
Draghi, Lorenza [1 ,2 ]
Tana, Francesca [1 ,2 ]
Fare, Silvia [1 ,2 ]
机构：
[1] Politecn Milan, Dept Chem Mat & Chem Engn Giulio Natta, Via Mancinelli 7, I-20131 Milan, Italy
[2] Natl Interuniv Consortium Mat Sci & Technol INSTM, Florence, Italy
来源：
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS | 2018年 / 41卷 / 06期
关键词：
Biopolymers; smart materials; thermo-responsive biopolymers; pH-responsive biopolymers; chemical-responsive biopolymers; medical device design; BIMOLECULAR FLUORESCENCE COMPLEMENTATION; REVERSIBLE XYLOGLUCAN GELS; DRUG-DELIVERY SYSTEM; MESENCHYMAL STEM-CELLS; THERMALLY RESPONSIVE POLYMERS; TISSUE-ENGINEERED CONSTRUCTS; BONE MORPHOGENETIC PROTEINS; ELASTIN-LIKE POLYPEPTIDE; INJURED SPINAL-CORD; IN-VITRO RELEASE;
D O I：
10.1177/0391398818765323
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Advances in regenerative medicine and in modern biomedical therapies are fast evolving and set goals causing an upheaval in the field of materials science. This review discusses recent developments involving the use of biopolymers as smart materials, in terms of material properties and stimulus-responsive behavior, in the presence of environmental physico-chemical changes. An overview on the transformations that can be triggered in natural-based polymeric systems (sol-gel transition, polymer relaxation, cross-linking, and swelling) is presented, with specific focus on the benefits these materials can provide in biomedical applications.
引用
收藏
页码：337 / 359
页数：23
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