Mifepristone dose in the regimen with misoprostol for medical abortion

被引：17

作者：

Marions, Lena ^{[1
]}

机构：

[1] Karolinska Univ Hosp Inst, Dept Obstet & Gynecol, S-17176 Stockholm, Sweden

来源：

CONTRACEPTION | 2006年 / 74卷 / 01期

关键词：

mitepristone; misoprostol; abortion; medical abortion; pregnancy termination;

D O I：

10.1016/j.contraception.2006.03.017

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Medical abortion with the antiprogesterone mifepristone followed by a prostaglandin is highly effective and widely used. The mifepristone dose registered is a single dose of 600 mg followed by a suitable prostaglandin analogue 36-48 h later. The 600-mg dose was chosen arbitrarily, and later studies have proven one third of this dose to be equally effective when combined with a prostaglandin analogue. This report reviews published data on the efficacy of mifepristone in different doses and demonstrates that there are no differences neither clinically nor in pharmacokinetics if the dose is reduced to 200 mg. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：21 / 25

页数：5

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