This essay presents a 2 years investigation regarding 450 Friesian cows reproduction capacity in Eastern Romania. We observed that the cows which calved between 20-25 months had a first lactation of 7389 kg milk, with a high percent of fat (4.17%) and proteins (3.37%). The heifers that calved in the first 26 to 31 months produced 7983 kg of milk with 4.03% fat and 3,24% proteins. The 594 kg of milk makes a significant difference for p<0.01 and confidence interval C.I.=95%. The regression parameters 0.439 and 44% underline the first calving age's average influence over milk production parameters. Reproduction abnormalities frequency during the entire analyzed period was between 4.5% (in January) and 12% in July; it was higher at the beginning of spring until the cold season. Heifers had a high degree of infertility (52.70%) followed by the cows at the 2nd calving (34.30%) and by those with multiple births (13.00%). Examining the reproduction activity and applying biotechnologies on milk cows maximizes the genetic process, the health and fertility, while the unitary production cost decreases.