Antiviral effects of statins

被引：52

作者：

Gorabi, Armita M. ^{[1
]}

Kiaie, Nasim ^{[1
]}

Bianconi, Vanessa ^{[2
]}

Jamialahmadi, Tannaz ^{[3
,4
,5
]}

Al-Rasadi, Khalid ^{[6
]}

Johnston, Thomas P. ^{[7
]}

Pirro, Matteo ^{[2
]}

Sahebkar, Amirhossein ^{[8
,9
,10
,11
]}

机构：

[1] Univ Tehran Med Sci, Res Ctr Adv Technol Cardiovasc Med, Tehran Heart Ctr, Tehran, Iran

[2] Univ Perugia, Dept Med, Unit Internal Med, Perugia, Italy

[3] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran

[4] Islamic Azad Univ, Quchan Branch, Dept Food Sci & Technol, Quchan, Iran

[5] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Razavi Khorasan, Iran

[6] Sultan Qaboos Univ Hosp, Dept Clin Biochem, Muscat, Oman

[7] Univ Missouri Kansas City, Sch Pharm, Div Pharmacol & Pharmaceut Sci, Kansas City, MO USA

[8] FDA, Halal Res Ctr IRI, Tehran, Iran

[9] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Razavi Khorasan, Iran

[10] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad 9177948564, Razavi Khorasan, Iran

[11] Polish Mothers Mem Hosp Res Inst PMMHRI, Lodz, Poland

来源：

PROGRESS IN LIPID RESEARCH | 2020年 / 79卷

关键词：

Statins; Virus; Infection; Pleiotropic; Cholesterol; HEPATITIS-C VIRUS; COA REDUCTASE INHIBITORS; COMBINATION THERAPY; HIV PATHOGENESIS; REPLICON SYSTEM; POTENTIAL ROLE; 1B INFECTION; LIPID RAFTS; IN-VIVO; CHOLESTEROL;

D O I：

10.1016/j.plipres.2020.101054

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Introducing statins as possible widely-available drugs for the treatment of viral infections requires an in depth review of their antiviral properties. Despite some inconsistency, a large body of literature data from experimental and clinical studies suggest that statins may have a role in the treatment of viral infections due to their immunomodulatory properties as well as their ability to inhibit viral replication. In the present review, the role that statins may play while interacting with the immune system during viral infections and the possible inhibitory effects of statins on different stages of virus cell cycle (i.e., from fusion with host cell membranes to extracellular release) and subsequent virus transmission are described. Specifically, cholesterol-dependent and cholesterol-independent mechanisms of the antiviral effects of statins are reported.

引用

页数：10

共 84 条

[1] Statins and outcomes of hospitalized patients with laboratory-confirmed 2017-2018 influenza [J].

Atamna, Alaa ;

Babitch, Tanya ;

Bracha, Mayaan ;

Sorek, Nadav ;

Haim, Ben-Zvi ;

Elis, Avishay ;

Bishara, Jihad ;

Avni, Tomer .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2019, 38 (12) :2341-2348

[2] Fluvastatin inhibits hepatitis C replication in humans [J].

Bader, Ted ;

Fazili, Javid ;

Madhoun, Mohammed ;

Aston, Christopher ;

Hughes, Diane ;

Rizvi, Syed ;

Seres, Ken ;

Hasan, Muhammad .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2008, 103 (06) :1383-1389

[3] Simvastatin potentiates the anti-hepatitis B virus activity of FDA-approved nucleoside analogue inhibitors in vitro [J].

Bader, Ted ;

Korba, Brent .

ANTIVIRAL RESEARCH, 2010, 86 (03) :241-245

[4] Are statins beneficial for viral pneumonia? [J].

Boyd, Angela R. ;

Mortensen, Eric M. .

EUROPEAN RESPIRATORY JOURNAL, 2013, 41 (05) :1010-1011

[5] Effect of addition of statins to antiviral therapy in hepatitis C virus-infected persons: Results from ERCHIVES [J].

Butt, Adeel A. ;

Yan, Peng ;

Bonilla, Hector ;

Abou-Samra, Abdul-Badi ;

Shaikh, Obaid S. ;

Simon, Tracey G. ;

Chung, Raymond T. ;

Rogal, Shari S. .

HEPATOLOGY, 2015, 62 (02) :365-374

[6]

Castejon A.M., 2016, IMMUNOTHERAPY ONCOLY

[7] Drug-Drug Interactions Between HMG-CoA Reductase Inhibitors (Statins) and Antiviral Protease Inhibitors [J].

Chauvin, Benoit ;

Drouot, Sylvain ;

Barrail-Tran, Aurelie ;

Taburet, Anne-Marie .

CLINICAL PHARMACOKINETICS, 2013, 52 (10) :815-831

[8] HIV-Nef Protein Transfer to Endothelial Cells Requires Rac1 Activation and Leads to Endothelial Dysfunction Implications for Statin Treatment in HIV Patients [J].

Chelvanambi, Sarvesh ;

Gupta, Samir K. ;

Chen, Xingjuan ;

Ellis, Bradley W. ;

Maier, Bernhard F. ;

Colbert, Tyler M. ;

Kuriakose, Jithin ;

Zorlutuna, Pinar ;

Jolicoeur, Paul ;

Obukhov, Alexander G. ;

Clauss, Matthias .

CIRCULATION RESEARCH, 2019, 125 (09) :805-820

[9] Impact of statin therapy on plasma adiponectin concentrations: A systematic review and meta-analysis of 43 randomized controlled trial arms [J].

Chrusciel, Piotr ;

Sahebkar, Amirhossein ;

Rembek-Wieliczko, Magdalena ;

Serban, Maria-Corina ;

Ursoniu, Sorin ;

Mikhailidis, Dimitri P. ;

Jones, Steven R. ;

Mosteoru, Svetlana ;

Blaha, Michael J. ;

Martin, Seth S. ;

Rysz, Jacek ;

Toth, Peter P. ;

Lip, Gregory Y. H. ;

Pencina, Michael J. ;

Ray, Kausik K. ;

Banach, Maciej .

ATHEROSCLEROSIS, 2016, 253 :194-208

[10] c-Src protein kinase inhibitors block assembly and maturation of dengue virus [J].

Chu, J. J. H. ;

Yang, Priscilla L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (09) :3520-3525

← 1 2 3 4 5 6 7 8 9 →