Investigating Microstructural Abnormalities and Neurocognition in Sub-Acute and Chronic Traumatic Brain Injury Patients with Normal-Appearing White Matter: A Preliminary Diffusion Tensor Imaging Study

被引:16
作者
Hashim, Eyesha [1 ]
Caverzasi, Eduardo [2 ,3 ]
Papinutto, Nico [2 ]
Lewis, Caroline E. [1 ]
Jing, Ruiwei [1 ]
Charles, Onella [1 ]
Zhang, Shudong [1 ]
Lin, Amy [4 ]
Graham, Simon J. [5 ]
Schweizer, Tom A. [1 ]
Bharatha, Aditya [6 ,7 ]
Cusimano, Michael D. [1 ,8 ]
机构
[1] St Michaels Hosp, Dept Neurosurg, Toronto, ON, Canada
[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA
[3] Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy
[4] St Michaels Hosp, Dept Radiol, Toronto, ON, Canada
[5] Univ Toronto, Sunnybrook Res Inst, Toronto, ON, Canada
[6] Univ Toronto, St Michaels Hosp, Dept Med Imaging, Toronto, ON, Canada
[7] Univ Toronto, Dept Med Imaging & Neurosurg, Toronto, ON, Canada
[8] Univ Toronto, Div Neurosurgery, Dept Surg, Fac Med, Toronto, ON, Canada
来源
FRONTIERS IN NEUROLOGY | 2017年 / 8卷
基金
加拿大健康研究院;
关键词
diffusion tensor imaging; chronic traumatic brain injury; white matter microstructure; human; voxel-based analysis; sub-acute traumatic brain injury; normal-appearing white matter; AXONAL INJURY; CORPUS-CALLOSUM; COGNITIVE IMPAIRMENT; MILD; MEMORY; MODERATE; NEUROANATOMY; DYSFUNCTION; INTEGRITY; FORNIX;
D O I
10.3389/fneur.2017.00097
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
For a significant percentage of subjects, with chronic traumatic brain injury (TBI), who report persisting cognitive impairment and functional loss, the diagnosis is often impeded by the fact that routine neuroimaging often does not reveal any abnormalities. In this paper, we used diffusion tensor imaging (DTI) to investigate the apparently normal white matter (as assessed by routine magnetic resonance imaging) in the brains of 19 subjects with sub-acute (9) and chronic (10) TBI. We also assessed memory, executive function, and visual-motor coordination in these subjects. Using a voxel-wise approach, we investigated if parameters of diffusion were significantly different between TBI subjects and 17 healthy controls (HC), who were demographically matched to the TBI group. We also investigated if changes in DTI parameters were associated with neuropsychological performance in either group. Our results indicate significantly increased mean and axial diffusivity (MD and AD, respectively) values in widespread brain locations in TBI subjects, while controlling for age, sex, and time since injury. HC performed significantly better than the TBI subjects on tests of memory and executive function, indicating the persisting functional loss in chronic TBI. We found no correlation between diffusion parameters and performance on test of executive function in either group. We found negative correlation between FA and composite memory scores, and positive correlation between RD and visuomotor coordination test scores, in various tracts in both groups. Our study suggests that changes in MD and AD can indicate persisting micro-structure abnormalities in normal-appearing white matter in the brains of subjects with chronic TBI. Our results also suggest that FA in major white matter tracts is correlated with memory in health and in disease, alike; larger and longitudinal studies are needed to discern potential differences in these correlations in the two groups.
引用
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页数:12
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