Sex: How Malaria Parasites Get Turned On

被引：5

作者：

Ankarklev, Johan ^{[1
]}

Brancucci, Nicolas M. B. ^{[1
]}

Goldowitz, Ilana ^{[1
]}

Mantel, Pierre-Yves ^{[1
]}

Marti, Matthias ^{[1
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

来源：

CURRENT BIOLOGY | 2014年 / 24卷 / 09期

关键词：

COMMITMENT; DIFFERENTIATION;

D O I：

10.1016/j.cub.2014.03.046

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanisms underlying sexual stage switching in Plasmodium spp. have hitherto remained a mystery. However, two recent studies have revealed that an apicomplexan-specific DNA-binding protein is essential for the initiation of this cell fate decision, ultimately providing the malaria community with a novel and important tool in the battle to prevent malaria transmission.

引用

页码：R368 / R370

页数：3

共 14 条

[1]

Balaji S., 2005, NUCL ACIDS RES, V33

[2] Commitment to gametocytogenesis in Plasmodium falciparum [J].

Dyer, M ;

Day, KP .

PARASITOLOGY TODAY, 2000, 16 (03) :102-107

[3] Mechanisms of germ cell specification across the metazoans: epigenesis and preformation [J].

Extavour, CG ;

Akam, M .

DEVELOPMENT, 2003, 130 (24) :5869-5884

[4] Plasmodium falciparum Heterochromatin Protein 1 Marks Genomic Loci Linked to Phenotypic Variation of Exported Virulence Factors [J].

Flueck, Christian ;

Bartfai, Richard ;

Volz, Jennifer ;

Niederwieser, Igor ;

Salcedo-Amaya, Adriana M. ;

Alako, Blaise T. F. ;

Ehlgen, Florian ;

Ralph, Stuart A. ;

Cowman, Alan F. ;

Bozdech, Zbynek ;

Stunnenberg, Hendrik G. ;

Voss, Till S. .

PLOS PATHOGENS, 2009, 5 (09)

[5] PLASMODIUM-BERGHEI - INVIVO GENERATION AND SELECTION OF KARYOTYPE MUTANTS AND NONGAMETOCYTE PRODUCER MUTANTS [J].

JANSE, CJ ;

RAMESAR, J ;

VANDENBERG, FM ;

MONS, B .

EXPERIMENTAL PARASITOLOGY, 1992, 74 (01) :1-10

[6] A transcriptional switch underlies commitment to sexual development in malaria parasites [J].

Kafsack, Bjoern F. C. ;

Rovira-Graells, Nuria ;

Clark, Taane G. ;

Bancells, Cristina ;

Crowley, Valerie M. ;

Campino, Susana G. ;

Williams, April E. ;

Drought, Laura G. ;

Kwiatkowski, Dominic P. ;

Baker, David A. ;

Cortes, Alfred ;

Llinas, Manuel .

NATURE, 2014, 507 (7491) :248-+

[7] Sexual differentiation and development in the malaria parasite [J].

Lobo, CA ;

Kumar, N .

PARASITOLOGY TODAY, 1998, 14 (04) :146-150

[8] Induction of mating in Candida albicans by construction of MTLa and MTLα strains [J].

Magee, BB ;

Magee, PT .

SCIENCE, 2000, 289 (5477) :310-313

[9] Malaria-Infected Erythrocyte-Derived Microvesicles Mediate Cellular Communication within the Parasite Population and with the Host Immune System [J].

Mantel, Pierre-Yves ;

Hoang, Anh N. ;

Goldowitz, Ilana ;

Potashnikova, Daria ;

Hamza, Bashar ;

Vorobjev, Ivan ;

Ghiran, Ionita ;

Toner, Mehmet ;

Irimia, Daniel ;

Ivanov, Alexander R. ;

Barteneva, Natasha ;

Marti, Matthias .

CELL HOST & MICROBE, 2013, 13 (05) :521-534

[10] The Apicomplexan AP2 family: Integral factors regulating Plasmodium development [J].

Painter, Heather J. ;

Campbell, Tracey L. ;

Llinas, Manuel .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2011, 176 (01) :1-7

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