The effects of running exercise on oligodendrocytes in the hippocampus of rats with depression induced by chronic unpredictable stress

被引：35

作者：

Tang, Jing ^{[1
,2
]}

Liang, Xin ^{[1
,2
]}

Zhang, Yang ^{[1
,2
]}

Chen, Linmu ^{[1
,2
]}

Wang, Feifei ^{[1
,2
]}

Tan, Chuanxue ^{[1
,2
]}

Luo, Yanmin ^{[1
,2
,3
]}

Xiao, Qian ^{[1
,2
,4
]}

Chao, Fenglei ^{[1
,2
]}

Zhang, Lei ^{[1
,2
]}

Gao, Yuan ^{[1
,2
,5
]}

Huang, Chunxia ^{[1
,2
,3
]}

Qi, Yingqiang ^{[1
,2
]}

Tang, Yong ^{[1
,2
]}

机构：

[1] Chongqing Med Univ, Dept Histol & Embryol, Chongqing 400016, Peoples R China

[2] Chongqing Med Univ, Lab Stem Cells & Tissue Engn, Chongqing 400016, Peoples R China

[3] Chongqing Med Univ, Dept Physiol, Chongqing 400016, Peoples R China

[4] Chongqing Med Univ, Dept Radioact Med, Chongqing 400016, Peoples R China

[5] Chongqing Med Univ, Affiliated Hosp 1, Dept Geriatr, Chongqing 400016, Peoples R China

来源：

BRAIN RESEARCH BULLETIN | 2019年 / 149卷

基金：

中国国家自然科学基金;

关键词：

Depression; Exercise; Hippocampus; Oligodendrocyte; Stereology; WHITE-MATTER; PREFRONTAL CORTEX; SUCROSE PREFERENCE; REDUCTION; MODEL; NEUROGENESIS; MYELINATION; EXPRESSION; DISORDER; PROTECTS;

D O I：

10.1016/j.brainresbull.2019.04.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Running exercise has been shown to be associated with decreased symptoms of depression. However, the mechanisms underlying these antidepressant effects of running exercise remain relatively unclear. In the current study, we investigated the relationship between depressive symptoms in chronic unpredictable stress (CUS) model rats treated with running exercise and changes in oligodendrocytes in the hippocampus. After 4 weeks of CUS, the model group was randomly divided into a CUS standard group (18 rats) and a CUS running group (15 rats). Then, a 4-week treadmill running trial was performed with the CUS running group. In addition, the behavioral effects of exercise were investigated by means of a sucrose preference test (SPT) and an at the end of the 8th week. Immunohistochemical methods and modem stereological methods were used to precisely quantify the total number of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase)-positive (CNPase(+)) oligodendrocytes in each hippocampal subregion. At the behavioral level, after four weeks of running, the CUS running group displayed significantly higher consumption of sucrose water in the SPT than the CUS standard group. Unbiased stereological analyses revealed significantly higher total numbers of CNPase(+) cells in the hippocampal CA3 and dentate gyms regions in the CUS running group than in the CUS standard group, whereas there was no significant difference between the groups in the number of CNPase(+) cells in the hippocampal CA1 region. The present results further confirm that exercise can alleviate symptoms and protect hippocampal oligodendrocytes in depressed rats.

引用

页码：1 / 10

页数：10

共 63 条

[1] Chronic unpredictable stress decreases cell proliferation in the cerebral cortex of the adult rat [J].