Potential role of "omics" technique in prenatal diagnosis of congenital heart defects

被引：7

作者：

Chen, Lizhu ^{[1
,2
]}

Guan, Johnny ^{[3
]}

Wei, Qiuju ^{[4
]}

Yuan, Zhengwei ^{[2
]}

Zhang, Mo ^{[5
]}

机构：

[1] China Med Univ, Shengjing Hosp, Dept Ultrasound, Shenyang 110004, Liaoning, Peoples R China

[2] China Med Univ, Shengjing Hosp, Minist Congenital Malformat, Key Lab Hlth, Shenyang 110004, Liaoning, Peoples R China

[3] Univ Calif Los Angeles, Dept Urol, Los Angeles, CA 90095 USA

[4] Univ Tennessee, Hlth Sci Ctr, Dept Obstet & Gynecol, Memphis, TN 38163 USA

[5] China Med Univ, Shengjing Hosp, Dept Urol, Shenyang 110004, Liaoning, Peoples R China

来源：

CLINICA CHIMICA ACTA | 2018年 / 482卷

基金：

中国国家自然科学基金;

关键词：

Congenital heart defect; Biomarkers; Omics; Prenatal diagnosis; MATERNAL PLASMA; 2ND TRIMESTER; NONINVASIVE BIOMARKERS; DOWNS-SYNDROME; MESSENGER-RNA; IDENTIFICATION; DISEASE; PREGNANCY; ABNORMALITIES; MICRORNAS;

D O I：

10.1016/j.cca.2018.04.011

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Congenital heart defect (CHD) is one of the most common birth defects and is the leading cause of neonatal death. Currently, there are no biomarkers available for prenatal diagnosis of CHD. Clinical strategies to diagnose CHD mostly depend on fetal echocardiography. Recent advances in "omics" techniques have opened up new possibilities for biomarker discoveries. In this review, we discuss recent advances in prenatal detection of CHD using biomarkers obtained by "omics" approaches, including genomics, proteomics, metabolomics, and others. There is great potential in obtaining various kinds of parameters using "omics" studies to facilitate early and accurate diagnosis of CHD.

引用

页码：185 / 190

页数：6

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