cGAS-STING signaling in cancer immunity and immunotherapy

被引：85
作者：
Du, Huashan [1 ]
Xu, Tianmin [1 ]
Cui, Manhua [1 ]
机构：
[1] Second Hosp Jilin Univ, Dept Gynecol & Obstet, 218 Ziqiang Rd, Changchun 130041, Jilin, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2021年 / 133卷
基金：
中国国家自然科学基金;
关键词：
cGAS-STING signaling; Cancer immunity; Cancer therapy; Antitumor; 5,6-DIMETHYLXANTHENONE-4-ACETIC ACID DMXAA; DNA SENSOR; DI-GMP; CHECKPOINT BLOCKADE; INTERFERON-BETA; SENESCENCE; INNATE; PROMOTES; CELLS; THERAPY;
D O I：
10.1016/j.biopha.2020.110972
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Recent studies have shown that the innate immune cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway may play an important role in antitumor immunity. Additionally, the cGAS-STING pathway promotes the senescence of cancer cells, induces apoptosis of cancer cells, and increases the protective effect of cytotoxic T cells and natural killer cell-mediated cytotoxicity. We believe that the combination of the cGAS-STING signaling pathway with other therapeutic methods provides a new perspective from which to overcome obstacles in the application of this review. Further, we highlight the antitumor mechanism of the cGAS-STING signaling pathway and the latest advances in monotherapy and combination therapy with related agonists.
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页数：10
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