HIV-1 Eracication: Early Trials (and Tribulations)

被引：98

作者：

Spivak, Adam M. ^{[1
]}

Planelles, Vicente ^{[2
]}

机构：

[1] Univ Utah, Sch Med, Dept Med, Salt Lake City, UT USA

[2] Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT 84132 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2016年 / 22卷 / 01期

基金：

美国国家卫生研究院;

关键词：

ACTIVE ANTIRETROVIRAL THERAPY; CD4(+) T-CELLS; IMMUNODEFICIENCY-VIRUS-INFECTION; REACTIVATES LATENT HIV-1; VALPROIC ACID; HIV-1-INFECTED PATIENTS; TREATMENT INTERRUPTION; RALTEGRAVIR INTENSIFICATION; RESERVOIR IMPLICATIONS; DEACETYLASE INHIBITOR;

D O I：

10.1016/j.molmed.2015.11.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antiretroviral therapy (ART) has rendered HIV-1 infection a manageable illness for those with access to treatment. However, ART does not lead to viral eradication owing to the persistence of replication-competent, unexpressed proviruses in long-lived cellular reservoirs. The potential for long-term drug toxicities and the lack of access to ART for most people living with HIV-1 infection have fueled scientific interest in understanding the nature of this latent reservoir. Exploration of HIV-1 persistence at the cellular and molecular level in resting memory CD4(+)T cells, the predominant viral reservoir in patients on ART, has uncovered potential strategies to reverse latency. We review recent advances in pharmacologically based 'shock and kill' HIV-1 eradication strategies, including comparative analysis of early clinical trials.

引用

页码：10 / 27

页数：18

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