Middle East Respiratory Syndrome Coronavirus Infection in Dromedary Camels in Saudi Arabia

被引：124

作者：

Alagaili, Abdulaziz N. ^{[1
,2
]}

Briese, Thomas ^{[3
]}

Mishra, Nischay ^{[3
]}

Kapoor, Vishal ^{[3
]}

Sameroff, Stephen C. ^{[3
]}

Burbelo, Peter D. ^{[4
]}

de Wit, Emmie ^{[5
]}

Munster, Vincent J. ^{[5
]}

Hensley, Lisa E. ^{[6
]}

Zalmout, Iyad S. ^{[1
]}

Kapoor, Amit ^{[3
]}

Epstein, Jonathan H. ^{[7
]}

Karesh, William B. ^{[7
]}

Daszak, Peter ^{[7
]}

Mohammed, Osama B. ^{[1
]}

Lipkin, W. Ian ^{[3
]}

机构：

[1] King Saud Univ, Coll Med, Dept Zool, KSU Mammals Res Chair, Riyadh 11461, Saudi Arabia

[2] Saudi Wildlife Author, Riyadh, Saudi Arabia

[3] Columbia Univ, Mailman Sch Publ Hlth, Ctr Infect & Immun, New York, NY USA

[4] NIH, Natl Inst Dent & Craniofacial Res, Dent Clin Res Core, Bethesda, MD 20892 USA

[5] NIAID, Virol Lab, Div Intramural Res, NIH,Rocky Mt Labs, Hamilton, MT USA

[6] NIAID, Integrated Res Facil, NIH, Frederick, MD USA

[7] EcoHlth Alliance, New York, NY USA

来源：

MBIO | 2014年 / 5卷 / 02期

基金：

美国国家卫生研究院;

关键词：

BATS;

D O I：

10.1128/mBio.00884-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Middle East respiratory syndrome (MERS) is proposed to be a zoonotic disease; however, the reservoir and mechanism for transmission of the causative agent, the MERS coronavirus, are unknown. Dromedary camels have been implicated through reports that some victims have been exposed to camels, camels in areas where the disease has emerged have antibodies to the virus, and viral sequences have been recovered from camels in association with outbreaks of the disease among humans. Nonetheless, whether camels mediate transmission to humans is unresolved. Here we provide evidence from a geographic and temporal survey of camels in the Kingdom of Saudi Arabia that MERS coronaviruses have been circulating in camels since at least 1992, are distributed countrywide, and can be phylogenetically classified into clades that correlate with outbreaks of the disease among humans. We found no evidence of infection in domestic sheep or domestic goats. IMPORTANCE This study was undertaken to determine the historical and current prevalence of Middle East respiratory syndrome (MERS) coronavirus infection in dromedary camels and other livestock in the Kingdom of Saudi Arabia, where the index case and the majority of cases of MERS have been reported.

引用

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