Exploring Polypharmacology and Molecular Promiscuity

被引：0

作者：

Bajorath, Juergen ^{[1
]}

机构：

[1] Rheinische Friedrich Wilhelms Univ, Dept Life Sci Informat, LIMES Program Unit Chem Biol & Med Chem, B IT, Endenicher Allee 19c, D-53115 Bonn, Germany

来源：

JOURNAL OF COMPUTER AIDED CHEMISTRY | 2019年 / 20卷

关键词：

Compound promiscuity; polypharmacology; kinase inhibitors; chemoinformatics; chemical biology;

D O I：

10.2751/jcac.20.43

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Multi-target activity (promiscuity) of small molecules provides the basis of drug polypharmacology. Computationally, promiscuity can be explored through systematic analysis of compound activity data. Inhibitors of the human kinome represent an instructive example

引用

页码：43 / 46

页数：4

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