Anticoagulation Therapy for Venous Thromboembolism in the Real World - From the COMMAND VTE Registry

被引：121

作者：

Yamashita, Yugo ^{[1
]}

Morimoto, Takeshi ^{[2
]}

Amano, Hidewo ^{[3
]}

Takase, Toru ^{[4
]}

Hiramori, Seiichi ^{[5
]}

Kim, Kitae ^{[6
]}

Konishi, Takashi ^{[7
]}

Akao, Masaharu ^{[8
]}

Kobayashi, Yohei ^{[9
]}

Inoue, Takeshi ^{[10
]}

Oi, Maki ^{[11
]}

Izumi, Toshiaki ^{[12
]}

Takahashi, Kotaro ^{[13
]}

Tada, Tomohisa ^{[13
]}

Chen, Po-Min ^{[14
]}

Murata, Koichiro ^{[15
]}

Tsuyuki, Yoshiaki ^{[16
]}

Sakai, Hiroshi ^{[17
]}

Saga, Syunsuke ^{[18
]}

Sasa, Tomoki ^{[19
]}

Sakamoto, Jiro ^{[20
]}

Yamada, Chinatsu ^{[21
]}

Kinoshita, Minako ^{[22
]}

Togi, Kiyonori ^{[23
]}

Ikeda, Tomoyuki ^{[24
]}

Ishii, Katsuhisa ^{[25
]}

Kaneda, Kazuhisa ^{[26
]}

Mabuchi, Hiroshi ^{[27
]}

Otani, Hideo ^{[28
]}

Takabayashi, Kensuke ^{[29
]}

Takahashi, Mamoru ^{[30
]}

Shiomi, Hiroki ^{[1
]}

Makiyama, Takeru ^{[1
]}

Ono, Koh ^{[1
]}

Kimura, Takeshi ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Kyoto, Japan

[2] Hyogo Coll Med, Dept Clin Epidemiol, Nishinomiya, Hyogo, Japan

[3] Kurashiki Cent Hosp, Dept Cardiovasc Med, Kurashiki, Okayama, Japan

[4] Kindai Univ Hosp, Dept Cardiol, Osaka, Japan

[5] Kokura Mem Hosp, Dept Cardiol, Kokura, Japan

[6] Kobe City Med Ctr Gen Hosp, Dept Cardiovasc Med, Kobe, Hyogo, Japan

[7] Japanese Red Cross Otsu Hosp, Dept Cardiol, Otsu, Shiga, Japan

[8] Natl Hosp Org Kyoto Med Ctr, Dept Cardiol, Kyoto, Japan

[9] Osaka Red Cross Hosp, Dept Cardiovasc Ctr, Osaka, Japan

[10] Shiga Med Ctr Adults, Dept Cardiol, Moriyama, Japan

[11] Japanese Red Cross Wakayama Med Ctr, Dept Cardiol, Wakayama, Japan

[12] Kitano Hosp, Tazuke Kofukai Med Res Inst, Cardiovasc Ctr, Osaka, Japan

[13] Shizuoka Prefectural Gen Hosp, Dept Cardiol, Shizuoka, Japan

[14] Osaka Saiseikai Noe Hosp, Dept Cardiol, Osaka, Japan

[15] Shizuoka City Shizuoka Hosp, Dept Cardiol, Shizuoka, Japan

[16] Shimada Municipal Hosp, Div Cardiol, Shimada, Japan

[17] Shiga Univ Med Sci, Dept Cardiovasc & Resp Med, Otsu, Shiga, Japan

[18] Hyogo Prefectural Amagasaki Gen Med Ctr, Dept Cardiol, Amagasaki, Hyogo, Japan

[19] Kishiwada City Hosp, Dept Cardiol, Kishiwada, Japan

[20] Tenri Hosp, Dept Cardiol, Tenri, Nara, Japan

[21] Kyoto Okamoto Mem Hosp, Dept Cardiovasc Med, Kyoto, Japan

[22] Nishikobe Med Ctr, Dept Cardiol, Kobe, Hyogo, Japan

[23] Kindai Univ, Fac Med, Div Cardiol, Nara Hosp, Ikoma, Japan

[24] Hikone Municipal Hosp, Dept Cardiol, Hikone, Japan

[25] Kansai Elect Power Hosp, Dept Cardiol, Osaka, Japan

[26] Mitsubishi Kyoto Hosp, Dept Cardiol, Kyoto, Japan

[27] Koto Mem Hosp, Dept Cardiol, Higashiomi, Japan

[28] Sugita Genpaku Mem Obama Municipal Hosp, Dept Cardiovasc Med, Obama, Fukui, Japan

[29] Hirakata Kohsai Hosp, Dept Cardiol, Hirakata, Osaka, Japan

[30] Shimabara Hosp, Dept Cardiol, Kyoto, Japan

来源：

CIRCULATION JOURNAL | 2018年 / 82卷 / 05期

关键词：

Anticoagulants; Bleeding; Mortality; Recurrence; Venous thromboembolism; ACUTE PULMONARY-EMBOLISM; DEEP-VEIN THROMBOSIS; RIETE REGISTRY; CLINICAL-PRACTICE; RISK-ASSESSMENT; MANAGEMENT; RECURRENCE; OUTCOMES; EPISODE; PREVENTION;

D O I：

10.1253/circj.CJ-17-1128

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Venous thromboembolism (VTE) has a long-term risk of recurrence, which can be prevented by anticoagulation therapy. Methods and Results: The COMMAND VTE Registry is a multicenter registry enrolling 3,027 consecutive patients with acute symptomatic VTE between January 2010 and August 2014. The entire cohort was divided into the transient risk (n=855, 28%), unprovoked (n=1,477, 49%), and cancer groups (n=695, 23%). The rate of anticoagulation discontinuation was highest in the cancer group (transient risk: 37.3% vs. unprovoked: 21.4% vs. cancer: 43.5% at 1 year, P<0.001). The cumulative 5-year incidences of recurrent VTE, major bleeding and all-cause death were highest in the cancer group (recurrent VTE: 7.9% vs. 9.3% vs. 17.7%, P<0.001; major bleeding: 9.0% vs. 9.4% vs. 26.6%, P<0.001; and all-cause death: 17.4% vs. 15.3% vs. 73.1%, P<0.001). After discontinuation of anticoagulation therapy, the cumulative 3-year incidence of recurrent VTE was lowest in the transient risk group (transient risk: 6.1% vs. unprovoked: 15.3% vs. cancer: 13.2%, P=0.001). The cumulative 3-year incidence of recurrent VTE beyond 1 year was lower in patients on anticoagulation than in patients off anticoagulation at 1 year in the unprovoked group (on: 3.7% vs. off: 12.2%, P<0.001), but not in the transient risk and cancer groups (respectively, 1.6% vs. 2.5%, P=0.30; 5.6% vs. 8.6%, P=0.44). Conclusions: The duration of anticoagulation therapy varied widely in discordance with current guideline recommendations. Optimal duration of anticoagulation therapy should be defined according to the risk of recurrent VTE and bleeding as well as death.

引用

页码：1262 / +

页数：12

共 31 条

[1] Duration of anticoagulation after venous thromboembolism in real world clinical practice [J].

Ageno, Walter ;

Samperiz, Angel ;

Caballero, Ruth ;

Dentali, Francesco ;

Di Micco, Pierpaolo ;

Prandoni, Paolo ;

Becattini, Cecilia ;

Uresandi, Fernando ;

Verhamme, Peter ;

Monreal, Manuel .

THROMBOSIS RESEARCH, 2015, 135 (04) :666-672

[2] Three months versus one year of oral anticoagulant therapy for idiopathic deep venous thrombosis. [J].

Agnelli, G ;

Prandoni, P ;

Santamaria, MG ;

Bagatella, P ;

Iorio, A ;

Bazzan, M ;

Moia, M ;

Guazzaloca, G ;

Bertoldi, A ;

Tomasi, C ;

Scannapieco, G ;

Ageno, W ;

Ascani, A ;

Villalta, S ;

Frulla, M ;

Mosena, L ;

Girolami, A ;

Vaccarino, A ;

Alatri, A ;

Palareti, G ;

Marchesi, M ;

Ambrosio, GB ;

Parisi, R ;

Doria, S ;

Steidl, L ;

Ambrosini, F ;

Silingardi, M ;

Ghirarduzzi, A ;

Iori, I .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (03) :165-169

[3] Guidelines for the Diagnosis, Treatment and Prevention of Pulmonary Thromboembolism and Deep Vein Thrombosis (JCS 2009) - Digest Version [J].

Ando, Motomi ;

Fukuda, Ikuo ;

Ito, Masaaki ;

Kobayashi, Takao ;

Masuda, Masahisa ;

Miyahara, Yoshiyuki ;

Nakanishi, Norifumi ;

Niwa, Akihiro ;

Ohgi, Shigetsugu ;

Tajima, Hiroyuki ;

Ishibashi, Hiroyuki ;

Kanaoka, Yasushi ;

Nakamura, Mashio ;

Sakuma, Masahito ;

Satoh, Toru ;

Tanabe, Nobuhiro ;

Yamada, Norikazu ;

Yamashita, Mitsuru ;

Kuriyama, Takayuki ;

Matsubara, Junichi ;

Nakano, Takeshi ;

Ozaki, Yukio ;

Sakata, Ryuzo .

CIRCULATION JOURNAL, 2011, 75 (05) :1258-1281

[4]

[Anonymous], EUR HEART J, DOI DOI 10.1093/EURHEARTJ/EHU283

[5] Edoxaban versus Warfarin for the Treatment of Symptomatic Venous Thromboembolism [J].

Bueller, Harry R. ;

Decousus, Herve ;

Grosso, Michael A. ;

Mercuri, Michele ;

Middeldorp, Saskia ;

Prins, Martin H. ;

Raskob, Gary E. ;

Schellong, Sebastian M. ;

Schwocho, Lee ;

Segers, Annelise ;

Shi, Minggao ;

Verhamme, Peter ;

Wells, Phil .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (15) :1406-1415

[6] Venous thromboembolism (VTE) in Europe - The number of VTE events and associated morbidity and mortality [J].

Cohen, Alexander T. ;

Agnelli, Giancarlo ;

Anderson, Frederick A. ;

Arcelus, Juan I. ;

Bergqvist, David ;

Brecht, Josef G. ;

Greer, Ian A. ;

Heit, John A. ;

Hutchinson, Julia L. ;

Kakkar, Ajay K. ;

Mottier, Dominique ;

Oger, Emmanuel ;

Samama, Meyer-Michel ;

Spannagl, Michael .

THROMBOSIS AND HAEMOSTASIS, 2007, 98 (04) :756-764

[7] Risk Assessment of Recurrence in Patients With Unprovoked Deep Vein Thrombosis or Pulmonary Embolism The Vienna Prediction Model [J].

Eichinger, Sabine ;

Heinze, Georg ;

Jandeck, Lisanne M. ;

Kyrle, Paul A. .

CIRCULATION, 2010, 121 (14) :1630-1636

[8] Predictors and Causes of Long-Term Mortality in Elderly Patients with Acute Venous Thromboembolism: A Prospective Cohort Study [J].

Faller, Nicolas ;

Limacher, Andreas ;

Mean, Marie ;

Righini, Marc ;

Aschwanden, Markus ;

Beer, Jurg Hans ;

Frauchiger, Beat ;

Osterwalder, Josef ;

Kucher, Nils ;

Lammle, Bernhard ;

Cornuz, Jacques ;

Angelillo-Scherrer, Anne ;

Matter, Christian M. ;

Husmann, Marc ;

Banyai, Martin ;

Staub, Daniel ;

Mazzolai, Lucia ;

Hugli, Olivier ;

Rodondi, Nicolas ;

Aujesky, Drahomir .

AMERICAN JOURNAL OF MEDICINE, 2017, 130 (02) :198-206

[9] A proportional hazards model for the subdistribution of a competing risk [J].

Fine, JP ;

Gray, RJ .

JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1999, 94 (446) :496-509

[10] Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER) [J].

Goldhaber, SZ ;

Visani, L ;

De Rosa, M .

LANCET, 1999, 353 (9162) :1386-1389

← 1 2 3 4 →