A thermosensitive chitosan-based hydrogel for controlled release of insulin

被引：24

作者：

Gao, Ting-Ting ^{[1
]}

Kong, Ming ^{[1
]}

Cheng, Xiao-Jie ^{[1
]}

Xia, Gui-Xue ^{[1
]}

Gao, Yuan-Yuan ^{[1
]}

Chen, Xi-Guang ^{[1
]}

Cha, Dong Su ^{[2
]}

Park, Hyun Jin ^{[2
]}

机构：

[1] Ocean Univ China, Coll Marine Life Sci, Qingdao 266003, Peoples R China

[2] Korea Univ, Coll Life Sci & Biotechnol, Seoul 136701, South Korea

来源：

FRONTIERS OF MATERIALS SCIENCE | 2014年 / 8卷 / 02期

基金：

中国国家自然科学基金; 国家教育部博士点专项基金资助;

关键词：

hydroxybutyl chitosan; hydrogel; thermosensitive; insulin; controlled release; HYDROXYBUTYL CHITOSAN; DELIVERY;

D O I：

10.1007/s11706-014-0247-7

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Present study aims at synthesizing a thermosensitive hydrogel for controlled release of insulin. According to a modified method, hydroxybutyl chitosan (HBC) hydrogel possessed thermal sensitivity is prepared which can form hydrogel at over 25 degrees C. The HBC hydrogel is non-cytotoxic to mice fibroblasts cells (L929). Insulin is 100% entrapped in the hydrogel, 38% of which is released in vitro from the concentration of 5% hydrogel after 48 h, whereas by enzymolysis with lysozyme, 80% of the total insulin is released after 48 h. This study suggests that HBC hydrogel could be utilized for controlled release of insulin in a non-invasive manner.

引用

页码：142 / 149

页数：8

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