Proteolysis of CD14 on human gingival fibroblasts by arginine-specific cysteine proteinases from Porphyromonas gingivalis leading to down-regulation of lipopolysaccharide-induced interleukin-8 production

被引：45

作者：

Tada, H

Sugawara, S

Nemoto, E

Takahashi, N

Imamura, T

Potempa, J

Travis, J

Shimauchi, H

Takada, H

机构：

[1] Tohoku Univ, Sch Dent, Dept Microbiol & Immunol, Aoba Ku, Sendai, Miyagi 9808575, Japan

[2] Tohoku Univ, Sch Dent, Dept Periodont & Endodont, Aoba Ku, Sendai, Miyagi 9808575, Japan

[3] Tohoku Univ, Sch Dent, Dept Oral Biochem, Aoba Ku, Sendai, Miyagi 9808575, Japan

[4] Kumamoto Univ, Grad Sch Med Sci, Dept Neurosci & Immunol, Div Mol Pathol, Kumamoto 8600811, Japan

[5] Jagiellonian Univ, Inst Mol Biol, Dept Microbiol & Immunol, PL-31120 Krakow, Poland

[6] Univ Georgia, Dept Biochem, Athens, GA 30602 USA

来源：

INFECTION AND IMMUNITY | 2002年 / 70卷 / 06期

关键词：

D O I：

10.1128/IAI.70.6.3304-3307.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Arginine-specific cysteine proteinases (gingipains-R) from periodontopathic Porphyromonas gingivalis cleaved CD14, a bacterial pattern recognition receptor, on human gingival fibroblasts (HGF). Consequently, gingipains-R reduced lipopolysaccharide-induced interleukin-8 production by HGF, indicating that gingipains-R inhibited CD14-dependent HGF activation and are involved in immune evasion by the bacterium in periodontal tissues.

引用

页码：3304 / 3307

页数：4

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