Epigenetic silencing of 14-3-3sigma in cancer

被引：58

作者：

Lodygin, Dmitri ^{[1
]}

Hermeking, Heiko ^{[1
]}

机构：

[1] Max Planck Inst Biochem, Independent Max Planck Res Grp, D-82152 Munich, Germany

来源：

SEMINARS IN CANCER BIOLOGY | 2006年 / 16卷 / 03期

关键词：

14-3-3; sigma; cell cycle; CpG methylation; p53; cancer; 14-3-3sigma;

D O I：

10.1016/j.semcancer.2006.03.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The 14-3-3 sigma gene is a direct target of the p53 tumor suppressor and its product inhibits cell cycle progression. Recently, a proteomic analysis revealed that 14-3-3 sigma regulates additional cellular processes relevant to carcinogenesis, as migration and MAP-kinase signalling. The expression of 14-3-3o- is down-regulated by CpG methylation in several types of human cancer, among them prostate, lung, breast and several types of skin cancer. The epigenetic inactivation of 14-3-3 sigma occurs at an early stage of tumor development and may allow evasion from senescence and promote genomic instability. In the future the detection of CpG methylation of 14-3-3 sigma may be used for diagnostic and prognostic purposes. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：214 / 224

页数：11

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