Electrochemiluminescence immunosensor based on graphene oxide nanosheets/polyaniline nanowires/CdSe quantum dots nanocomposites for ultrasensitive determination of human interleukin-6

被引：55
作者：
Liu, Ping-Zhen [1 ]
Hu, Xiao-Wei [1 ]
Mao, Chang-Jie [1 ]
Niu, He-Lin [1 ]
Song, Ji-Ming [1 ]
Jin, Bao-Kang [1 ]
Zhang, Sheng-Yi [1 ]
机构：
[1] Anhui Univ, Sch Chem & Chem Engn, Hefei 230039, Peoples R China
来源：
ELECTROCHIMICA ACTA | 2013年 / 113卷
基金：
中国国家自然科学基金;
关键词：
Electrochemiluminescence immunosensor; Graphene oxide nanosheets/polyaniline nanowire/CdSe quantum dots; Human interleukin-6; ELECTROGENERATED CHEMILUMINESCENCE; NANOCRYSTALS; ELECTROCHEMISTRY;
D O I：
10.1016/j.electacta.2013.09.074
中图分类号：
O646 [电化学、电解、磁化学];
学科分类号：
081704 ;
摘要：
A novel graphene oxide nanosheets/polyaniline nanowires/CdSe quantum dots (GO/PANi/CdSe) nanocomposites are successfully synthesized and use as ECL immunosensor for detection of human interleukin-6 (IL-6). The as-prepared GO/PANi/CdSe nanocomposites show excellent biocompatibility, dispersity and solubility. Electrochemiluminescence (ECL) of CdSe quantudm dots (QDs) was greatly enhanced by combining with GO/PANi nanocomposites. Herein, this GO/PANi/CdSe nanocomposite was applied to develop an ultrasensitive ECL immunosensor for detection of IL-6. The ECL immunosensor has a sensitive response to IL-6 in a linear range of 0.0005-10 ng mL(-1). The prepared ECL immunosensor exhibits high specificity, long-term stability and excellent reproducibility with a detection limit of 0.17 pg mL(-1). (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：176 / 180
页数：5
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