Hematopoietic stem cell transplantation for pulmonary alveolar proteinosis associated with primary immunodeficiency disease

被引：12

作者：

Tanaka-Kubota, Mari ^{[1
]}

Shinozaki, Koji ^{[2
]}

Miyamoto, Satoshi ^{[1
]}

Yanagimachi, Masakatsu ^{[1
]}

Okano, Tsubasa ^{[1
]}

Mitsuiki, Noriko ^{[1
]}

Ueki, Masahiro ^{[3
]}

Yamada, Masafumi ^{[3
]}

Imai, Kohsuke ^{[4
]}

Takagi, Masatoshi ^{[4
]}

Agematsu, Kazunaga ^{[2
,5
]}

Kanegane, Hirokazu ^{[1
]}

Morio, Tomohiro ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Pediat & Dev Biol, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138519, Japan

[2] Shinshu Univ, Sch Med, Dept Pediat, Matsumoto, Nagano, Japan

[3] Hokkaido Univ, Dept Pediat, Grad Sch Med, Sapporo, Hokkaido, Japan

[4] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Community Pediat Perinatal & Maternal Med, Tokyo, Japan

[5] Shinshu Univ, Grad Sch Med, Dept Infect & Host Def, Matsumoto, Nagano, Japan

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2018年 / 107卷 / 05期

关键词：

Pulmonary alveolar proteinosis; Hematopoietic stem cell transplantation; Primary immunodeficiency; Granulocyte-macrophage colony stimulating factor; Bronchoalveolar lavage; GM-CSF; DEFICIENCY; MUTATIONS;

D O I：

10.1007/s12185-017-2375-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pulmonary alveolar proteinosis (PAP) is a rare disorder that is characterized by the excessive accumulation of surfactant-like materials in the alveoli, leading to hypoxemic respiratory failure. We describe two Japanese infants with PAP associated with hypogammaglobulinemia and monocytopenia. These patients may have underlying primary immunodeficiency (PID) and were successfully treated with allogeneic hematopoietic stem cell transplantation (HSCT). This report indicates that allogeneic HSCT may provide a curative treatment for PAP associated with PID.

引用

页码：610 / 614

页数：5

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