Treatment of isolated central nervous system relapse in high-risk lymphoid malignancy with allogeneic bone marrow transplantation and extended intrathecal therapy

被引：9
作者：
Nagatoshi, Y
Kawano, Y
Nagayama, J
Okamura, J
机构：
[1] Kyushu Natl Canc Ctr, Sect Pediat, Minami Ku, Fukuoka 8111395, Japan
[2] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Pediat, Kagoshima 890, Japan
[3] Kyushu Natl Canc Ctr, Inst Clin Res, Fukuoka, Japan
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2004年 / 125卷 / 06期
关键词：
central nervous system relapse; acute lymphoblastic leukaemia; allogeneic bone marrow transplantation; extended intrathecal therapy;
D O I：
10.1111/j.1365-2141.2004.04975.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We performed allogeneic bone marrow transplantation (BMT) with an extended period of post-transplant intrathecal (IT) chemotherapy for five patients with acute lymphoblastic leukaemia and non-Hodgkin's lymphoma who had relapsed in the central nervous system either in the very early phase or more than twice. Post-transplant IT was scheduled for a total of 12 doses over 18 months. One patient was found to have subclinical leucoencephalopathy. Disease relapse occurred in one patient and the other patients remained in complete remission for 39-196 months post-BMT. The estimated event-free survival was 80 +/- 17.9% (standard error).
引用
收藏
页码：766 / 768
页数：3
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