Association between PTGER4 polymorphisms and inflammatory bowel disease risk in Caucasian A meta-analysis

被引：3

作者：

Wu, Peng-Bo ^{[1
]}

Qian, Rao ^{[1
]}

Hong, Chai ^{[1
]}

Guo, Yi-tian ^{[1
]}

Yu, Yuan-jie ^{[1
]}

Zhang, Guo ^{[2
]}

Tan, Shi-Yun ^{[1
]}

机构：

[1] Wuhan Univ, Renmin Hosp, Dept Gastroenterol, 238 Jiefang Rd, Wuhan, Hubei, Peoples R China

[2] Guangxi People Hosp, Dept Gastroenterol, Nanning, Guangxi Zhuang, Peoples R China

来源：

MEDICINE | 2020年 / 99卷 / 34期

关键词：

inflammatory bowel disease; meta-analysis; polymorphism; PTGER4; GENOME-WIDE ASSOCIATION; CROHNS-DISEASE; SUSCEPTIBILITY LOCI; ULCERATIVE-COLITIS; RECEPTOR; GENE; MORTALITY; VARIANTS; MULTIPLE; SURVIVAL;

D O I：

10.1097/MD.0000000000019756

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: The results from previous studies on association between prostaglandin E receptor 4 (PTGER4) polymorphisms and inflammatory bowel disease (IBD) risk in Caucasian were conflict. The present study aimed to investigate the genetic association by conducting a meta-analysis. Methods: Systematic literature search was conducted through Wiley Online Library, Chinese National Knowledge Infrastructure (CNKI), and PubMed databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to investigate the associations between rs4613763 T/C, 17234657T/G polymorphisms, and IBD risk in Caucasian. Results: Twenty case-control studies consisting of 18,495 Crohn disease (CD) patients and 4203 ulcerative colitis (UC) patients, as well as 26,063 controls were included in this meta-analysis. The rs4613763T/C polymorphism had obvious influence on CD, UC risk in Caucasian. However, rs17234657T/G polymorphism had obvious influence on CD but not UC in Caucasian. Conclusion: This meta-analysis suggested that both the rs4613763 T/C, rs17234657T/G polymorphisms had obvious influence on risk of CD in Caucasian. In addition, rs4613763 T/C, polymorphism had obvious influence on risk of UC in Caucasian.

引用

页数：5

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