Sphingosine-1-phosphate and calcium signaling in cerebellar astrocytes and differentiated granule cells

被引：15

作者：

Giussani, Paola ^{[1
]}

Ferraretto, Anita ^{[1
]}

Gravaghi, Claudia ^{[1
]}

Bassi, Rosaria ^{[1
]}

Tettamanti, Guido ^{[1
]}

Riboni, Laura ^{[1
]}

Viani, Paola ^{[1
]}

机构：

[1] LITA, Dept Med Chem Biochem & Biotechnol, I-20090 Segrate, Milan, Italy

来源：

NEUROCHEMICAL RESEARCH | 2007年 / 32卷 / 01期

关键词：

sphingosine-1-phosphate; cerebellar astrocytes; cerebellar granule cells; calcium signalling; videoimaging;

D O I：

10.1007/s11064-006-9219-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

S1P is involved in the regulation of multiple biological processes (cell survival, growth, migration and differentiation) both in neurons and glial cells. The study was aimed at investigating the possible effects of S1P on calcium signaling in cerebellar astrocytes and differentiated granule cells. In cerebellar astrocytes S1P is able to mediate calcium signaling mainly through G(i) protein coupled receptors, whereas in differentiated neurons it failed to evoke any calcium signaling, despite acting both extracellularly and intracellularly. The data indicate strict cell specificity in S1P-evoked calcium response, which could be relevant to communication between neurons and glial cells in the cerebellum.

引用

页码：27 / 37

页数：11

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