Biomedical polymers: synthesis, properties, and applications

被引：138

作者：

Chen, Wei-Hai ^{[1
,2
]}

Chen, Qi-Wen ^{[1
,2
]}

Chen, Qian ^{[3
]}

Cui, Chunyan ^{[4
]}

Duan, Shun ^{[5
]}

Kang, Yongyuan ^{[6
]}

Liu, Yang ^{[7
]}

Liu, Yun ^{[8
,9
]}

Muhammad, Wali ^{[6
]}

Shao, Shiqun ^{[10
,11
,12
]}

Tang, Chengqiang ^{[13
,14
]}

Wang, Jinqiang ^{[8
,9
]}

Wang, Lei ^{[15
]}

Xiong, Meng-Hua ^{[16
]}

Yin, Lichen ^{[17
]}

Zhang, Kuo ^{[15
]}

Zhang, Zhanzhan ^{[7
]}

Zhen, Xu ^{[18
]}

Feng, Jun ^{[1
,2
]}

Gao, Changyou ^{[6
]}

Gu, Zhen ^{[8
,9
]}

He, Chaoliang ^{[19
]}

Ji, Jian ^{[6
]}

Jiang, Xiqun ^{[18
]}

Liu, Wenguang ^{[4
]}

Liu, Zhuang ^{[3
]}

Peng, Huisheng ^{[13
,14
]}

Shen, Youqing ^{[10
,11
,12
]}

Shi, Linqi ^{[7
]}

Sun, Xuemei ^{[13
,14
]}

Wang, Hao ^{[15
]}

Wang, Jun ^{[16
]}

Xiao, Haihua ^{[20
]}

Xu, Fu-Jian ^{[5
]}

Zhong, Zhiyuan ^{[21
,22
,23
]}

Zhang, Xian-Zheng ^{[1
,2
]}

Chen, Xuesi ^{[19
]}

机构：

[1] Wuhan Univ, Key Lab Biomed Polymers, Minist Educ, Wuhan 430072, Peoples R China

[2] Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China

[3] Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Peoples R China

[4] Tianjin Univ, Sch Mat Sci & Engn, Tianjin Key Lab Composite & Funct Mat, Tianjin 300350, Peoples R China

[5] Beijing Univ Chem Technol, Coll Mat Sci & Engn, Beijing Lab Biomed Mat, Minist Educ,Key Lab Biomed Mat Nat Macromol, Beijing 100029, Peoples R China

[6] Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Peoples R China

[7] Nankai Univ, Coll Chem, State Key Lab Med Chem Biol, Key Lab Funct Polymer Mat,Minist Educ, Tianjin 300071, Peoples R China

[8] Zhejiang Univ, Coll Pharmaceut Sci, Key Lab Adv Drug Delivery Syst Zhejiang Prov, Hangzhou 310058, Peoples R China

[9] Zhejiang Univ, Jinhua Inst, Jinhua 321299, Zhejiang, Peoples R China

[10] Zhejiang Univ, Coll Chem & Biol Engn, Zhejiang Key Lab Smart BioMat, Hangzhou 310027, Peoples R China

[11] Zhejiang Univ, Coll Chem & Biol Engn, Ctr Bionanoengn, Hangzhou 310027, Peoples R China

[12] ZJU Hangzhou Global Sci & Technol Innovat Ctr, Hangzhou 311215, Peoples R China

[13] Fudan Univ, Dept Macromol Sci, State Key Lab Mol Engn Polymers, Shanghai 200438, Peoples R China

[14] Fudan Univ, Lab Adv Mat, Shanghai 200438, Peoples R China

[15] CAS Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol NCNST, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

[16] South China Univ Technol, Sch Biomed Sci & Engn, Guangzhou Int Campus, Guangzhou 510006, Peoples R China

[17] Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Peoples R China

[18] Nanjing Univ, Coll Chem & Chem Engn, Dept Polymer Sci & Engn, Nanjing 210093, Peoples R China

[19] Chinese Acad Sci, Changchun Inst Appl Chem, CAS Key Lab Polymer Ecomat, Changchun 130022, Peoples R China

[20] Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China

[21] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Biomed Polymers Lab, Suzhou 215123, Peoples R China

[22] Soochow Univ, State Key Lab Radiat Med & Protect, Suzhou 215123, Peoples R China

[23] Soochow Univ, Coll Pharmaceut Sci, Suzhou 215123, Peoples R China

来源：

SCIENCE CHINA-CHEMISTRY | 2022年 / 65卷 / 06期

基金：

中国国家自然科学基金;

关键词：

biomedical polymer; nanomedicine; cancer therapy; drug delivery; bioimaging and biosensing; tissue engineering; regenerative medicine; cytotoxicity; biocompatibility; TARGETED DRUG-DELIVERY; SURFACE-MEDIATED TRANSFECTION; MRI CONTRAST AGENT; IN-VIVO; ENDOTHELIAL-CELLS; T-CELLS; CANCER-IMMUNOTHERAPY; CARBON NANOTUBES; RATIONAL DESIGN; REACTIVE OXYGEN;

D O I：

10.1007/s11426-022-1243-5

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation.

引用

页码：1010 / 1075

页数：66

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