In vitro activity of terbinafine associated to amphotericin B, fluvastatin, rifampicin, metronidazole and ibuprofen against Pythium insidiosum

被引：26

作者：

Cavalheiro, Ayrton S. ^{[1
]}

Zanette, Regis A. ^{[1
]}

Spader, Tatiana B. ^{[1
]}

Lovato, Luciane ^{[1
]}

Azevedo, Maria Isabel ^{[1
]}

Botton, Sonia ^{[1
]}

Alves, Sydney H. ^{[1
]}

Santurio, Janio M. ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Dept Microbiol & Parasitol, Lab Pesquisas Micol, BR-97105900 Santa Maria, RS, Brazil

来源：

VETERINARY MICROBIOLOGY | 2009年 / 137卷 / 3-4期

关键词：

Pythiosis; Pythium insidiosum; Fungus-like; Terbinafine; Broth microdilution; Antifungal activity; CANDIDA-ALBICANS; ITRACONAZOLE; FLUCONAZOLE; VORICONAZOLE; COMBINATION; CASPOFUNGIN; PYTHIOSIS; THERAPY; ANIMALS; AGENT;

D O I：

10.1016/j.vetmic.2009.01.036

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We evaluated the in vitro activities of terbinafine alone and in combination with amphotericin B, fluvastatin, rifampicin, metronidazole or ibuprofen against 17 clinical isolates of Pythium insidiosum. The assays were based on technique M38-A2, as well as the checkerboard microdilution method. The main synergism observed was by combination of terbinafine plus amphotericin B (41.18%). Antagonisms were observed in combinations of terbinafine with fluvastatin (35.30%) or rifampicin (5.88%). (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：408 / 411

页数：4

共 17 条

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