An efficient approach to access 1,1,2-triarylethanes enabled by the organo-photoredox-catalyzed decarboxylative addition reaction

被引：29
作者：
Guo, Jing [1 ]
Huang, Gong-Bin [1 ]
Wu, Qiao-Lei [1 ]
Xie, Ying [1 ]
Weng, Jiang [1 ]
Lu, Gui [1 ]
机构：
[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Design & Evaluat, Guangzhou 510006, Guangdong, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2019年 / 6卷 / 12期
关键词：
PARA-QUINONE METHIDES; ASYMMETRIC 1,6-CONJUGATE ADDITION; ALPHA-AMINO-ACIDS; C-H BONDS; VISIBLE-LIGHT; CARBOXYLIC-ACIDS; EOSIN Y; CONJUGATE ADDITIONS; QUATERNARY CENTERS; ARYL HALIDES;
D O I：
10.1039/c9qo00380k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient protocol for the synthesis of 1,1,2-triarylethanes and 2,2-diarylethylamine with biological and pharmacological potential via organo-photoredox-catalyzed decarboxylative 1,6-conjugate addition of carboxylic acids to para-quinone methides has been developed. Different from the traditional transition-metal catalyzed multi-step synthetic strategy, our process involves a photoredox-promoted free radical pathway. A variety of structurally diverse products can be easily obtained under metal-free conditions in good to excellent yields (38 examples, up to 98% yield) in one step.
引用
收藏
页码：1955 / 1960
页数：6
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