Studies of the β-sheet mediated self-assembly of designed synthetic peptides of general formula PhCO-Gly-Xx-OCH2Ph and the possible role of aromatic π-π interactions in the self-assembly

被引：3

作者：

Dutta, Arpita ^{[1
]}

Kar, Sudeshna ^{[1
]}

Froehlich, Roland ^{[2
]}

Koley, Pradyot ^{[1
]}

Pramanik, Animesh ^{[1
]}

机构：

[1] Univ Calcutta, Dept Chem, Kolkata 700009, W Bengal, India

[2] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany

来源：

ARKIVOC | 2009年

关键词：

Peptides; self-assembly; supramolecular beta-sheet; aromatic pi-pi interactions; ribbon like structures; PARKINSONS-DISEASE; ALPHA-SYNUCLEIN; LEWY BODIES; SOLID-STATE; AMINO-ACIDS; FIBRILS; AGGREGATION; FIBRILLOGENESIS; MINERALIZATION; CONFORMATION;

D O I：

10.3998/ark.5550190.0010.724

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A set of three peptides 1-3 of general formula PhCO-Gly-Xx-OCH2Ph, where Xx is Gly in peptide 1, Ala in 2 and Aib (alpha-animo isobutyric acid) in 3 has been chosen to study the self-assembly and the morphology of the solid biomaterials. FT-IR and single crystal X-ray diffraction studies reveal that the peptides 1-3 self-assemble to form supramolecular beta-sheet structures through intermolecular hydrogen bonds and aromatic pi-pi interactions. Field emission scanning electron micrographs (FE-SEM) of the dried materials of the peptides 1-3 show the formation of flat ribbon like structures which are formed through beta-sheet mediated self-assembly.

引用

页码：247 / 259

页数：13

共 3 条

[1] Effects of mutations in de novo designed synthetic amphiphilic β-sheet peptides on self-assembly of fibrils
Raz, Yoav
Rubinov, Boris
Matmor, Maayan
Rapaport, Hanna
Ashkenasy, Gonen
Miller, Yifat
CHEMICAL COMMUNICATIONS, 2013, 49 (58) : 6561 - 6563
[2] Studies of Amyloid-Like Fibrillogenesis through β-Sheet-Mediated Self-Assembly of Short Synthetic Peptides
Dutt, Anita
Spencer, Elinor C.
Howard, Judith A. K.
Pramanik, Animesh
CHEMISTRY & BIODIVERSITY, 2010, 7 (02) : 363 - 375
[3] Role of Side Chains in β-Sheet Self-Assembly into Peptide Fibrils. IR and VCD Spectroscopic Studies of Glutamic Acid-Containing Peptides
Tobias, Fernando
Keiderling, Timothy A.
LANGMUIR, 2016, 32 (18) : 4653 - 4661

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