Increased oxidative/nitrosative stress and decreased antioxidant enzyme activities in prostate cancer

被引：104

作者：

Arsova-Sarafinovska, Zorica ^{[2
]}

Eken, Ayse ^{[1
]}

Matevska, Nadica ^{[3
]}

Erdem, Onur ^{[1
]}

Sayal, Ahmet ^{[1
]}

Savaser, Ayhan ^{[1
]}

Banev, Saso ^{[4
]}

Petrovski, Daniel ^{[5
]}

Dzikova, Sonja ^{[6
]}

Georgiev, Vladimir ^{[5
]}

Sikole, Aleksandar ^{[6
]}

Ozgok, Yasar ^{[7
]}

Suturkova, Ljubica ^{[3
]}

Dimovski, Aleksandar J. ^{[3
]}

Aydin, Ahmet ^{[1
]}

机构：

[1] Gulhane Mil Med Acad, Dept Toxicol, Ankara, Turkey

[2] Republ Inst Hlth Protect, Dept Drug Qual Control, Skopje, North Macedonia

[3] Univ St Cyril & Methodius, Fac Pharm, Skopje, North Macedonia

[4] Univ St Cyril & Methodius, Fac Med, Inst Pathol, Skopje, North Macedonia

[5] Univ Clin Urol, Skopje, North Macedonia

[6] Univ Clin Nephrol, Skopje, North Macedonia

[7] Gulhane Mil Med Acad, Dept Urol, Ankara, Turkey

来源：

CLINICAL BIOCHEMISTRY | 2009年 / 42卷 / 12期

关键词：

Prostate cancer; Oxidative stress; Antioxidant enzymes; Nitric oxide; Benign prostatic hyperplasia; 8-hydroxy-2 '-deoxyguanosine; NITRIC-OXIDE SYNTHASE; OXIDATIVE DNA-DAMAGE; LIPID-PEROXIDATION; OXYGEN RADICALS; INFLAMMATION; PLASMA; MARKER; 8-HYDROXY-2'-DEOXYGUANOSINE; ASSOCIATION; MECHANISMS;

D O I：

10.1016/j.clinbiochem.2009.05.009

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objectives: The study was aimed to evaluate the oxidative/nitrosative stress status in prostate cancer (CaP) and benign prostatic hyperplasia (BPH). Design and methods: 312 men from two different populations were included: 163 men from Macedonia (73 Cap patients, 67 BPH patients and 23 control 'subjects) and 149 men from Turkey (34 prostate cancer patients, 100 BPH patients and 15 control Subjects). We measured erythrocyte malondialdehyde (MDA) levels, erythrocyte activities of superoxide dismutase (CuZn-SOD), glutathione peroxidase (GPX) and catalase (CAT); plasma nitrite/nitrate (NO2-/NO3-, cGMP and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels. Results: A similar pattern of alteration in the oxidative/nitrosative stress-related parameters was found in both, Macedonian and Turkish studied samples: higher MDA concentrations with lower GPX and CuZn-SOD activities in Cap patients versus controls and BPH groups. The CAT activity was decreased in the CaP patients versus controls in the Turkish studied sample. Furthermore, CaP patients had increased plasma NO2-/NO3- and cGMP levels versus controls and BPH groups in both studied samples. Conclusions: This study has confirmed an imbalance in the oxidative stress/antioxidant status and revealed an altered nitrosative status in prostate cancer patients. (C) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：1228 / 1235

页数：8

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