Dysiarenone, a Dimeric C21 Meroterpenoid with Inhibition of COX-2 Expression from the Marine Sponge Dysidea arenaria

被引：36

作者：

Jiao, Wei-Hua ^{[1
]}

Cheng, Bao-Hui ^{[2
,3
]}

Chen, Guo-Dong ^{[4
]}

Shi, Guo-Hua ^{[1
]}

Li, Jing ^{[1
]}

Hu, Tian-Yong ^{[2
,3
]}

Lin, Hou-Wen ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Ren Ji Hosp, Dept Pharm,Res Ctr Marine Drugs,State Key Lab Onc, Shanghai 200127, Peoples R China

[2] Longgang ENT Hosp, Shenzhen Key Lab ENT, Shenzhen 518172, Peoples R China

[3] Inst ENT, Shenzhen 518172, Peoples R China

[4] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 10期

基金：

中国国家自然科学基金;

关键词：

SESQUITERPENE QUINONES; NATURAL-PRODUCTS; A-C; AMINOQUINONES; PUUPEHENONE; AVARA;

D O I：

10.1021/acs.orglett.8b01148

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dysiarenone (1), a dimeric C-21 meroterpenoid featuring an unprecedented 2-oxaspiro[bicyclo[3.3.1]nonane-9,1'-cyclopentane] carbon skeleton, was isolated from the marine sponge Dysidea arenaria. The structure of 1 was determined by HRMS and NMR spectroscopic analyses coupled with ECD calculations. Dysiarenone showed inhibitory activities against COX-2 expression and the production of prostaglandin E-2 with an IC50 value of 6.4 mu M in LPS-stimulated RAW264.7 macrophages.

引用

页码：3092 / 3095

页数：4

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