Bak (and Bax) to the future - of primary melanoma prognosis?

被引：7

作者：

Leverkus, Martin ^{[1
]}

Gollnick, Harald ^{[1
]}

机构：

[1] Otto Von Guericke Univ, Dept Dermatol & Venerol, Lab Expt Dermatol, D-39120 Magdeburg, Germany

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2006年 / 126卷 / 06期

关键词：

D O I：

10.1038/sj.jid.5700239

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Bcl-2 proteins either block or activate the "intrinsic" mitochondrial apoptosis pathway. Loss of expression of proapoptotic Bcl-2 proteins, namely Bax and Bak, in primary melanomas is associated with a worse long-term prognosis. Consequently, inactivation of mitochondrial signaling pathways of apoptosis may not only be a prerequisite for melanoma progression but may also hamper therapeutic efforts with chemotherapeutic drugs.

引用

页码：1212 / 1214

页数：4

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